FlyBase Allele Report: Dmel\Cul2[EY09124]

General Information

Symbol

Dmel\Cul2^EY09124

Species

D. melanogaster

Name

FlyBase ID

FBal0159375

Feature type

allele

Associated gene

Dmel\Cul2

Associated Insertion(s)

P{EPgy2}Cul2^EY09124

Carried in Construct

Also Known As

cul-2^EY, P{EPgy2}cul-2^EY09124

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Gene Disruption Project members, 2001-)

Progenitor genotype

Associated Insertion(s)

P{EPgy2}Cul2^EY09124

Cytology

Description

Allele components

Component

Use(s)

Inserted element

P{EPgy2}

misexpression element

Regulatory region(s)

UASp

binary expression system - regulatory region

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

2L:21,659,019..21,659,019 [+]

(Sanhueza et al., 2015, Ayyub, 2011, Gene Disruption Project members, 2001-)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates amyotrophic lateral sclerosis type 8

modeled by Vap33^{P58S.UAS.Tag:FLAG}

(Sanhueza et al., 2015)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy (with Cul2⁰²⁰⁷⁴)

(Ayyub, 2011)

female sterile

(Ayyub, 2011)

fertile

(Gene Disruption Project members, 2001-)

viable

(Ayyub, 2011, Gene Disruption Project members, 2001-)

Phenotype Manifest In

egg chamber

(Ayyub, 2011)

germarium

(Ayyub et al., 2015, Ayyub, 2011)

NMJ bouton | larval stage | increased number (with Cul2⁰²⁰⁷⁴)

(Ayyub, 2011)

nurse cell

(Ayyub, 2011)

oocyte

(Ayyub, 2011)

spectrosome

(Ayyub et al., 2015)

stalk follicle cell

(Ayyub, 2011)

terminal filament

(Ayyub, 2011)

Detailed Description

Statement

Reference

Germaria from adult Cul2^EY09124 mutant females display increased number of spectrosome-containing cells compared to controls.

(Ayyub et al., 2015)

Cul-2^EY09124/Cul-2⁰²⁰⁷⁴ larvae show a significant increase in bouton number (counted from muscles 6 and 7 of abdominal segment A2), compared to controls.

Egg chambers from Cul-2^EY09124 females show pleiotropic defects including: extra nurse cells, absent nurse cells, degraded nurse cells, oocyte in the middle of the egg chamber, thin germarium, absent terminal filament, missing interfollicular stalks.

(Ayyub, 2011)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhanced by

Statement

Reference

Cul2^EY09124 has abnormal neuroanatomy phenotype, non-enhanceable by Cul5^EY21463

(Ayyub, 2011)

Enhancer of

Statement

Reference

Cul2^EY09124, Scer\GAL4^GMR.PF is an enhancer of visible phenotype of Scer\GAL4^GMR.PF, cindr^{RNAi.PC.PD.UAS}

(Ketosugbo et al., 2017)

NOT Enhancer of

Statement

Reference

Cul2^EY09124 is a non-enhancer of abnormal neuroanatomy phenotype of Cul5^EY21463

(Ayyub, 2011)

Phenotype Manifest In

NOT Enhanced by

Statement

Reference

Cul2^EY09124 has NMJ bouton | larval stage | increased number phenotype, non-enhanceable by Cul5^EY21463

(Ayyub, 2011)

Cul2^EY09124 has egg chamber phenotype, non-enhanceable by Cul5^EY21463

(Ayyub, 2011)

Enhancer of

Statement

Reference

Cul2^EY09124, Scer\GAL4^GMR.PF is an enhancer of eye phenotype of Scer\GAL4^GMR.PF, cindr^{RNAi.PC.PD.UAS}

(Ketosugbo et al., 2017)

NOT Enhancer of

Statement

Reference

Cul2^EY09124 is a non-enhancer of NMJ bouton | larval stage | increased number phenotype of Cul5^EY21463

(Ayyub, 2011)

Cul2^EY09124 is a non-enhancer of egg chamber phenotype of Cul5^EY21463

(Ayyub, 2011)

Additional Comments

Genetic Interactions

Statement

Reference

Cul-2^EY09124, Cul-5^EY21463 double mutants show a similar increase in bouton number at the larval neuromuscular junction as either single mutant.

Cul-2^EY09124, Cul-5^EY21463 double mutants show similar egg chamber defects as either single mutant.

(Ayyub, 2011)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

19883

y¹ w^67c23; P{EPgy2}Cul2^EY09124

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

Cul-2^EY09124

Cul2^EY09124

(Ayyub et al., 2015)

cul-2^EY09124

cul-2^EY

(Ayyub et al., 2015, Ayyub, 2011)

cul2^EY

(Ayyub, 2011)

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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