FlyBase Allele Report: Dmel\Cul5[EY00051]

General Information

Symbol

Dmel\Cul5^EY00051

Species

D. melanogaster

Name

FlyBase ID

FBal0159374

Feature type

allele

Associated gene

Dmel\Cul5

Associated Insertion(s)

P{EPgy2}Cul5^EY00051

Carried in Construct

Also Known As

cul-5^EY00051

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Gene Disruption Project members, 2001-)

Progenitor genotype

Associated Insertion(s)

P{EPgy2}Cul5^EY00051

Cytology

Description

Allele components

Component

Use(s)

Inserted element

P{EPgy2}

misexpression element

Regulatory region(s)

UASp

binary expression system - regulatory region

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

3R:29,062,966..29,062,966 [-]

(Ayyub, 2011, Gene Disruption Project members, 2001-)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal cell number | adult stage

(Kugler et al., 2010)

abnormal cell number | adult stage (with Cul5^EY21463)

(Kugler et al., 2010)

abnormal neuroanatomy, with Scer\GAL4^elav.PU

(Ayyub, 2011)

Phenotype Manifest In

egg chamber

(Kugler et al., 2010)

egg chamber (with Cul5^EY21463)

(Kugler et al., 2010)

NMJ bouton | larval stage | increased number, with Scer\GAL4^elav.PU

(Ayyub, 2011)

Detailed Description

Statement

Reference

Larvae expressing Cul-5^EY00051 under the control of Scer\GAL4^elav.PU show an increase in bouton number at the neuromuscular junction.

(Ayyub, 2011)

Ovarioles from homozygous Cul-5^EY00051 1-2 day old flies contain egg chambers that have more than the 16 germ cells seen in wild type.

Follicles containing more than 16 germ cells are present in the ovarioles of 1-2 day old Cul-5^EY21463/Cul-5^EY00051 flies.

(Kugler et al., 2010)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Cul5^EY00051, Scer\GAL4^elav.PU has abnormal neuroanatomy phenotype, suppressible by Cul2^GD8913, Scer\GAL4^elav.PU

(Ayyub, 2011)

NOT Enhancer of

Statement

Reference

Cul5^EY00051, Scer\GAL4^GMR.PF is a non-enhancer of visible phenotype of Scer\GAL4^GMR.PF, cindr^{RNAi.PC.PD.UAS}

(Ketosugbo et al., 2017)

NOT Suppressor of

Statement

Reference

Cul5^EY00051, Scer\GAL4^GMR.PF is a non-suppressor of visible phenotype of Scer\GAL4^GMR.PF, cindr^{RNAi.PC.PD.UAS}

(Ketosugbo et al., 2017)

Phenotype Manifest In

Suppressed by

Statement

Reference

Cul5^EY00051, Scer\GAL4^elav.PU has NMJ bouton | increased number | larval stage phenotype, suppressible by Cul2^GD8913, Scer\GAL4^elav.PU

(Ayyub, 2011)

Enhancer of

Statement

Reference

Cul5^EY00051/Cul-5[+] is an enhancer of embryonic/larval cuticle phenotype of baz⁴

(Shao et al., 2010)

Cul5^EY00051/Cul-5[+] is an enhancer of embryonic/larval cuticle phenotype of baz^G0484

(Shao et al., 2010)

NOT Enhancer of

Statement

Reference

Cul5^EY00051, Scer\GAL4^GMR.PF is a non-enhancer of eye phenotype of Scer\GAL4^GMR.PF, cindr^{RNAi.PC.PD.UAS}

(Ketosugbo et al., 2017)

NOT Suppressor of

Statement

Reference

Cul5^EY00051, Scer\GAL4^GMR.PF is a non-suppressor of eye phenotype of Scer\GAL4^GMR.PF, cindr^{RNAi.PC.PD.UAS}

(Ketosugbo et al., 2017)

Additional Comments

Genetic Interactions

Statement

Reference

Co-expression of Cul-2^GD8913 decreases the number of boutons seen by Scer\GAL4^elav.PU-mediated expression of Cul-5^EY00051 to levels seen by expression of Cul-2^GD8913 alone.

(Ayyub, 2011)

The cuticle phenotype of dead embryos derived from baz⁴/+ embryos derived from a cross of baz⁴/+ females to wild-type males is enhanced if the females also carry one copy of Cul-5^EY00051.

The cuticle phenotype of dead embryos derived from baz^G0484/+ embryos derived from a cross of baz^G0484/+ females to wild-type males is enhanced if the females also carry one copy of Cul-5^EY00051.

(Shao et al., 2010)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

16535

y¹ w^67c23; P{EPgy2}Cul5^EY00051/TM3, Sb¹ Ser¹

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Cul-5^EY00051

Cul5^EY00051

cul-5^EY00051

(Ayyub, 2011, Kugler et al., 2010)

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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