FlyBase Allele Report: Dmel\stv[1]

General Information

Symbol

Dmel\stv¹

Species

D. melanogaster

Name

FlyBase ID

FBal0191602

Feature type

allele

Associated gene

Dmel\stv

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Coulson et al., 2005)

Progenitor genotype

Cytology

Description

Amino acid replacement: Q210term.

(Coulson et al., 2005)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3L:13,481,483..13,481,483 [+]

Nucleotide change:

C13481483T

Amino acid change:

Reported amino acid change:

Q210term

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change. Reported amino acid substitution refers to stv-PA but is one residue off from the reference genomic sequence.

(Coulson et al., 2005)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal body size | P-stage, with Scer\GAL4^Mef2.PU, stv^HMJ02221

(Pueyo et al., 2023)

abnormal body size | P-stage (with stv⁰⁰⁵⁴³)

(Brooks et al., 2020)

abnormal feeding behavior | larval stage | rescuable maternal effect (with stv²)

(Coulson et al., 2005)

abnormal flight | dominant

(Arndt et al., 2010)

abnormal locomotor behavior | dominant

(Arndt et al., 2010)

lethal (with stv^3c)

(Coulson et al., 2005)

lethal (with stv⁴)

(Coulson et al., 2005)

lethal | recessive

(Coulson et al., 2005)

lethal - all die before end of first instar larval stage | rescuable maternal effect (with stv²)

(Coulson et al., 2005)

partially lethal (with stv⁰⁰⁵⁴³)

(Brooks et al., 2020)

some die during first instar larval stage | rescuable maternal effect (with stv²)

(Coulson et al., 2005)

Phenotype Manifest In

embryonic/larval somatic muscle cell | third instar larval stage (with stv⁰⁰⁵⁴³)

(Brooks et al., 2020)

mouth hook (with stv³)

(Coulson et al., 2005)

Z disc

(Arndt et al., 2010)

Detailed Description

Statement

Reference

stv¹/stv⁰⁰⁵⁴³ exhibit larval muscle defects and elongated pupae (possibly due to impaired muscle contraction during the larval to pupal transition).

(Brooks et al., 2020)

In muscles of the gastrointestinal tract, Z lines are no longer detectable in stv¹ homozygotes. Homozygous stv¹ mutant larvae behave poorly in locomotion assays.

Heterozygous stv¹/+ animals that develop to adult flies suffer from a constant decline of climbing and flying activities during aging, which is accompanied by disruption of Z disc structures.

(Arndt et al., 2010)

stv¹/stv² larvae derived from females containing stv^- germline clones die during the first larval instar. stv¹/stv² larvae derived from females containing stv^- germline clones show severely reduced or no detectable food uptake. Those larvae that show no food uptake do not grow from their hatching size, and those that do show some food uptake show only a minimal amount of growth compared to their zygotically rescued siblings. stv¹/stv³ larvae derived from females containing stv^- germline clones show only a slight delay in development, however some of these larvae show a failure of the second instar and third instar mouth hooks to separate, preventing the completion of the second moult. stv¹/stv² embryos derived from females containing stv^- germline clones have a normal somatic muscle pattern.