FB2024_03 , released June 25, 2024
Allele: Hsap\PAX65a.UAS
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General Information
Symbol
Hsap\PAX65a.UAS
Species
H. sapiens
Name
FlyBase ID
FBal0183192
Feature type
allele
Associated gene
Hsap\PAX6
Associated Insertion(s)
Carried in Construct
P{UAS-PAX6.5a}
Key Links
Transgenic product class
cDNA
(Dominguez et al., 2004)
wild_type
(Dominguez et al., 2004)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Dominguez et al., 2004)
wild_type
(Dominguez et al., 2004)
Mutagen
in vitro construct
(Dominguez et al., 2004)
Progenitor genotype
Carried in construct
P{UAS-PAX6.5a}
Cytology
Description

UASt regulatory sequences drive expression of of a 1.5kb XbaI-XhoI fragment containing full-length Hsap\PAX6 cDNA from the 5a isoform, which lacks the N-terminal subdomain.

(Dominguez et al., 2004)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Hsap\PAX6
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Clones expressing Scer\GAL4Act5C.PI>Hsap\PAX65a.Scer\UAS are significantly larger than wild-type control clones.

      (Tanaka-Matakatsu et al., 2015)

      Expression of Hsap\PAX65a.Scer\UAS, under the control of Scer\GAL4dpp.blk1, causes eye reduction but does not induce an extra ventral eye.

      (Yao and Sun, 2005)

      Overexpression of Hsap\PAX65a.Scer\UAS, driven by Scer\GAL4dpp.blk1, in the wing disc induces marked wing outgrowths. This expression also causes extended larval development (up to five days), resulting in eight day-old larvae that have wing discs with huge overgrowths, many abnormal compartments, highly irregular organization of anterior and posterior compartments and failure to differentiate. The size of the notum region is not affected.

      (Dominguez et al., 2004)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Expression of Hsap\PAX65a.Scer\UAS, under the control of Scer\GAL4eyg-22-2, enhances the eyg22-2/eygM3-12 mutant eye and thorax phenotypes.

      (Yao and Sun, 2005)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Hsap\PAX65a.Scer\UAS
      Hsap\PAX65a.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (3)