FB2024_03 , released June 25, 2024
Allele: Dmel\Lk62
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General Information
Symbol
Dmel\Lk62
Species
D. melanogaster
Name
FlyBase ID
FBal0182928
Feature type
allele
Associated gene
Dmel\Lk6
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Arquier et al., 2005)
Mutagen
P-element activity
(Arquier et al., 2005)
Progenitor genotype
Lk6EP3333
(Arquier et al., 2005)
Cytology
Description

Deletion removing all Lk6 exons 3' of the P{EP}Lk6EP3333 progenitor insertion site.

(Arquier et al., 2005)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      exacerbates  multiple endocrine neoplasia type 2B
      modeled by RetMEN2B.UAS
      (Sonoshita et al., 2018)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Lethality acts in the second larval instar; affected larvae show dramatic growth defects. Lk61/Lk62 flies have reduced viability (45% lethality) and 20% mass reduction in adult males or 25% reduction in adult females. Larvae show growth defects, evident in fat body and salivary glands. Fat body cell size reduced by 30%. Reduced cell number, not size, underlies adult wing growth reduction of 12%.

      (Arquier et al., 2005)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      Lk62 is an enhancer of visible phenotype of Scer\GAL4bbg-C96, mamH.UAS

      (Kwon et al., 2013)

      Lk62 is an enhancer of visible phenotype of Scer\GAL4bbg-C96, domRNAi.Sym.UAS

      (Kwon et al., 2013)
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      Lk62 is an enhancer of wing margin phenotype of Scer\GAL4bbg-C96, mamH.UAS

      (Kwon et al., 2013)

      Lk62 is an enhancer of wing margin phenotype of Scer\GAL4bbg-C96, domRNAi.Sym.UAS

      (Kwon et al., 2013)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The wing nicking phenotype caused by expression of domdsRNA.Sym.Scer\UAS under the control of Scer\GAL4bbg-C96 is enhanced if the flies are also carrying Lk62.

      The wing nicking phenotype caused by expression of mamH.Scer\UAS under the control of Scer\GAL4bbg-C96 is enhanced if the flies are also carrying Lk62.

      (Kwon et al., 2013)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      Lk61/Lk62 is rescued by Lk6UAS.cAa/Scer\GAL4da.G32

      (Arquier et al., 2005)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      LK62
      (Sonoshita et al., 2018, Kwon et al., 2013)
      Lk62
      Name Synonyms
      Secondary FlyBase IDs
        References (3)