FB2024_03 , released June 25, 2024
Allele: Dmel\Lk61
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General Information
Symbol
Dmel\Lk61
Species
D. melanogaster
Name
FlyBase ID
FBal0182931
Feature type
allele
Associated gene
Dmel\Lk6
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Arquier et al., 2005)
Mutagen
P-element activity
(Arquier et al., 2005)
Progenitor genotype
Lk6EP3333
(Arquier et al., 2005)
Cytology
Description

3kb deletion removing an alternative 5' exon but leaving intact the rest of the coding region such that Lk6-RB is affected but Lk6-RA is not.

(Arquier et al., 2005)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygotes show 20% lethality. Adults merge with a 1-2 day delay. Males show a 13% body mass reduction and females show a 20% body mass reduction. Lk61/Lk62 flies have reduced viability (45% lethality) and 20% mass reduction in adult males or 25% reduction in adult females. Larvae show growth defects, evident in fat body and salivary glands. Fat body cell size reduced by 30%. Reduced cell number, not size, underlies adult wing growth reduction of 12%.

      (Arquier et al., 2005)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      Lk61/Lk62 is rescued by Lk6UAS.cAa/Scer\GAL4da.G32

      (Arquier et al., 2005)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Lk61
      Name Synonyms
      Secondary FlyBase IDs
        References (1)