FB2024_03 , released June 25, 2024
Allele: Dmel\mip40EY16520
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General Information
Symbol
Dmel\mip40EY16520
Species
D. melanogaster
Name
FlyBase ID
FBal0178875
Feature type
allele
Associated gene
Dmel\mip40
Associated Insertion(s)
P{EPgy2}mip40EY16520
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Gene Disruption Project members, 2001-)
Progenitor genotype
Associated Insertion(s)
P{EPgy2}mip40EY16520
Cytology
Description

Insertion into the coding sequence, 181bp from the ATG codon.

(Beall et al., 2007)
Allele components
Component
Use(s)
Inserted element
P{EPgy2}
Regulatory region(s)
UASp
Mutations Mapped to the Genome
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Embryos derived from females carrying homozygous mip40EY16520 germline clones crossed to wild type males are able to hatch at a similar rate to wild type.

      (Lewis et al., 2012)

      Most homozygous females are completely sterile, while a few give rise to one or two larvae after 7 days of egg laying.

      Many nuclei within homozygous stage 10 egg chambers have a normal BrdU incorporation pattern (in four foci). However, within the same mutant egg chamber at this stage there are also nuclei that have BrdU incorporation spread throughout the entire nucleus.

      Homozygous males are sterile. The mutant testes completely lack mature sperm and development appears to be arrested at the primary spermatocyte stage, prior to the G2-M transition.

      (Beall et al., 2007)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      mip40EY16520 is a suppressor of lethal | larval stage phenotype of lin-5293

      (Lewis et al., 2012)
      NOT Suppressor of
      Statement
      Reference

      mip40[+]/mip40EY16520 is a non-suppressor of lethal | larval stage phenotype of lin-5293

      (Lewis et al., 2012)

      mip40[+]/mip40EY16520 is a non-suppressor of lethal | germline clone | maternal effect | embryonic stage phenotype of lin-5293

      (Lewis et al., 2012)
      Phenotype Manifest In
      NOT Suppressor of
      Statement
      Reference

      mip40[+]/mip40EY16520 is a non-suppressor of embryo | germline clone | maternal effect phenotype of lin-5293

      (Lewis et al., 2012)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      mip40EY16520 rescues the lethality seen in homozygous and hemizygous lin-5293 larvae. Both male and female adult flies are seen at a similar frequency to controls. One copy of mip40EY16520 is not sufficient to rescue the lethality.

      Embryos derived from females that carry homozygous lin-5293 mutant germline clones and are heterozygous for mip40EY16520 crossed to wild type males are unable to hatch, similar to when females are maternally mutant for lin-5293 alone.

      (Lewis et al., 2012)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      mip40EY16520 is rescued by mip40+tBa

      (Beall et al., 2007)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      mip40EY16520
      (Laktionov et al., 2018, Debruhl et al., 2013, Lewis et al., 2012, Beall et al., 2007)
      Name Synonyms
      Secondary FlyBase IDs
        References (5)