FB2024_03 , released June 25, 2024
Allele: Dmel\mysb45
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General Information
Symbol
Dmel\mysb45
Species
D. melanogaster
Name
FlyBase ID
FBal0178735
Feature type
allele
Associated gene
Dmel\mys
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Jannuzi et al., 2004)
Progenitor genotype
Cytology
Description

Amino acid replacement: R312Q.

(Jannuzi et al., 2004)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
X:8,067,180..8,067,180 [+]
Nucleotide change:

G8067180A

Amino acid change:

R312Q | mys-PA; R312Q | mys-PB; R312Q | mys-PC; R312Q | mys-PD

Reported amino acid change:

R312Q

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Jannuzi et al., 2004)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Mutants show normal location of photoreceptor nuclei in the retina.

      (Curtin et al., 2005)

      Moderate allele.

      (Jannuzi et al., 2004)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      mysb45 is an enhancer of neuron & eye photoreceptor cell | somatic clone phenotype of Bsgδ265

      (Curtin et al., 2005)

      mysb45 is an enhancer of neuron & eye photoreceptor cell | somatic clone phenotype of Bsgk13638

      (Curtin et al., 2005)
      Other
      Statement
      Reference

      mewM6, mysb45 has neuron & eye photoreceptor cell phenotype

      (Curtin et al., 2005)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The phenotype of mild displacement of photoreceptor nuclei that is seen in the retina of mosaic animals in which the eyes are homozygous for Bsgk13638 is enhanced if the animals are also hemizygous for mysb45.

      The severity of the displacement of photoreceptor nuclei phenotype that is seen in the retina of mosaic animals in which the eyes are homozygous for Bsgδ265 is enhanced if the animals are also hemizygous for mysb45.

      mewM6 mysb45 double heterozygotes show displacement of photoreceptor nuclei in the retina in 3% of cases.

      (Curtin et al., 2005)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Selected as: a mutation that permits the survival of an F1 male.

      (Jannuzi et al., 2004)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      mysb45
      (Curtin et al., 2005)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)