FlyBase Allele Report: Dmel\InR[ex52.1]

General Information

Symbol

Dmel\InR^ex52.1

Species

D. melanogaster

Name

FlyBase ID

FBal0176094

Feature type

allele

Associated gene

Dmel\InR

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

decreased occurrence of cell division | germline clone

(Yu et al., 2009)

Phenotype Manifest In

female germline stem cell | germline clone

(Yu et al., 2009)

Detailed Description

Statement

Reference

Homozygous female germline stem cells show a strong reduction in division index compared to controls.

(Yu et al., 2009)

InR^ex52.1/+ mutant third instar larval eye discs do not show disrupted axon targeting from photoreceptor neurons to the brain optic lobes.

(Shcherbata et al., 2007)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

InR^ex52.1 has decreased occurrence of cell division | germline clone phenotype, suppressible | partially by dap[+]/dap⁴

(Yu et al., 2009)

InR^ex52.1 has decreased occurrence of cell division | germline clone phenotype, suppressible | partially by dap^2X10/dap[+]

(Yu et al., 2009)

Other

Statement

Reference

Dg³²³, InR[+]/InR^ex52.1 has abnormal neuroanatomy | third instar larval stage phenotype

(Shcherbata et al., 2007)

Phenotype Manifest In

Suppressed by

Statement

Reference

InR^ex52.1 has female germline stem cell | germline clone phenotype, suppressible | partially by dap[+]/dap⁴

(Yu et al., 2009)

InR^ex52.1 has female germline stem cell | germline clone phenotype, suppressible | partially by dap^2X10/dap[+]

(Yu et al., 2009)

Other

Statement

Reference

Dg³²³, InR[+]/InR^ex52.1 has eye disc | third instar larval stage phenotype

(Shcherbata et al., 2007)

Dg³²³, InR[+]/InR^ex52.1 has eye photoreceptor cell | third instar larval stage phenotype

(Shcherbata et al., 2007)

Dg³²³, InR[+]/InR^ex52.1 has lamina plexus | third instar larval stage phenotype

(Shcherbata et al., 2007)

Additional Comments

Genetic Interactions

Statement

Reference

The reduced cell division index of InR^ex52.1 female germline stem cell clones can be partially rescued by dap⁴/+ or by dap^2X10/+.

(Yu et al., 2009)

Dys^8-2/InR^ex52.1 double heterozygous mutant third instar larval eye discs do not show disrupted axon targeting from photoreceptor neurons to the brain optic lobes.

InR^ex52.1/Df(3R)Dl-X43 double heterozygous mutant third instar larval eye discs do not show disrupted axon targeting from photoreceptor neurons to the brain optic lobes.

Dg³²³/+; InR^ex52.1/+ double heterozygous mutant third instar larval eye discs show disrupted axon targeting from photoreceptor neurons to the brain optic lobes.

(Shcherbata et al., 2007)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

InR^ex52.1

(Yu et al., 2009, Shcherbata et al., 2007)

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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