FB2024_03 , released June 25, 2024
Allele: Dmel\matse03077
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General Information
Symbol
Dmel\matse03077
Species
D. melanogaster
Name
FlyBase ID
FBal0162328
Feature type
allele
Associated gene
Dmel\mats
Associated Insertion(s)
PBac{RB}matse03077
Carried in Construct
Key Links
Genomic Maps

Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(He et al., 2005)
Mutagen
piggyBac activity
(Bloomington Drosophila Stock Center, 2004.11.6)
Progenitor genotype
Associated Insertion(s)
PBac{RB}matse03077
Cytology
Description
Allele components
Component
Use(s)
Inserted element
PBac{RB}
Also carries
FRT
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      matse03077 homozygous mutant embryos display a significant increase in the frequency of hemisegments with abnormal number of neurons in the asymmetrically dividing RP2 neural lineage.

      (Keder et al., 2015)

      Homozygous and hemizygous second instar larvae have many split denticles per segment.

      Homozygous clones in the wing can result in bulging of the wing surface. The cells in these clones appear to have a bulging apical surface and the wing hairs are located on an elevated pedestal. The wing hairs are often broader than normal.

      Homozygous clones in the wing can sometimes result in discrete outgrowths. Many cells in these outgrowths appear to have multiple wing hairs.

      Homozygous clones can result in abnormal pigmentation and outgrowths of clone tissue are seen.

      Homozygous clones in the pupal wing sometimes have a multiple wing hair phenotype. In many of the clones, hair initiation and outgrowth appear to be advanced compared to the neighbouring wild-type cells. If clones are induced early, the mutant cells are able to outcompete their wild-type neighbours and end up comprising most of the wing.

      (He et al., 2005)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhanced by
      Statement
      Reference

      matse03077 has abnormal neuroanatomy | embryonic stage phenotype, enhanceable by ykiB5/ykiB5

      (Keder et al., 2015)
      Enhancer of
      Statement
      Reference

      matse03077/mats[+] is an enhancer of visible phenotype of Scer\GAL4ptc-559.1, trcT453A.UAS.L

      (He et al., 2005)
      Other
      Statement
      Reference

      cno2, matse03077/mats[+] has abnormal neuroanatomy | embryonic stage phenotype

      (Keder et al., 2015)

      fry1/fry[+], matse03077, trc[+]/trcS066917a has visible | dominant phenotype

      (He et al., 2005)

      fry2/fry[+], matse03077, trc1/trc[+] has visible | dominant phenotype

      (He et al., 2005)
      Phenotype Manifest In
      Enhanced by
      Statement
      Reference

      matse03077 has larval RP2 motor neuron | embryonic stage phenotype, enhanceable by ykiB5/ykiB5

      (Keder et al., 2015)
      Enhancer of
      Statement
      Reference

      matse03077/mats[+] is an enhancer of wing hair | increased number phenotype of Scer\GAL4ptc-559.1, trcT453A.UAS.L

      (He et al., 2005)
      Other
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The high frequency of hemisegments with abnormal number of neurons in the asymmetrically dividing RP2 neural lineage characteristic for matse03077 homozygous mutant embryos is increased further by combination with ykiB5 in homozygous state.

      The proportion of hemisegments with abnormal number of neurons in the asymmetrically dividing RP2 neural lineage is significantly increased in cno2/+;matse03077/+ double heterozygous embryos compared to either of the single heterozygotes or wild type.

      (Keder et al., 2015)

      The multiple wing hair phenotype that is caused by expression of trcT453A.Scer\UAS under the control of Scer\GAL4ptc-559.1 is dominantly enhanced by matse03077.

      fry1 trcS066917a matse03077 triple heterozygotes have a weak multiple wing hair phenotype in 40% of wings.

      fry2 trc1 matse03077 triple heterozygotes have a weak multiple wing hair phenotype in 41% of wings.

      The split denticle phenotype of matse03077 trcS066917a double mutant second instar larvae is no more severe than the split denticle phenotype of each single mutant.

      (He et al., 2005)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      matse235

      (He et al., 2005)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      CG13852e03077
      (Gene Disruption Project members and Exelixis, 2005)
      matsP
      (He et al., 2005)
      matsPB
      (He et al., 2005)
      matse03077
      (Keder et al., 2015, Vrabioiu and Struhl, 2015)
      Name Synonyms
      Secondary FlyBase IDs
        References (5)