FB2024_03 , released June 25, 2024
Allele: Dmel\Dh31KG09001
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General Information
Symbol
Dmel\Dh31KG09001
Species
D. melanogaster
Name
FlyBase ID
FBal0160615
Feature type
allele
Associated gene
Dmel\Dh31
Associated Insertion(s)
P{SUPor-P}Dh31KG09001
Carried in Construct
Key Links
Genomic Maps

Allele class

hypomorphic allele - genetic evidence

hypomorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Kunst et al., 2014)

hypomorphic allele - molecular evidence

(Kunst et al., 2014)
Mutagen
P-element activity
(Gene Disruption Project members, 2001-)
Progenitor genotype
Associated Insertion(s)
P{SUPor-P}Dh31KG09001
Cytology
Description

Insertion in the third intron

(Kunst et al., 2014)
Mutations Mapped to the Genome
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Dh31KG09001/Dh31KG09001 and Dh31KG09001/Df(2L)Exel7038 flies show significantly more nighttime sleep than controls (the amount of daytime sleep is unaffected). The increase in nighttime sleep occurs in the second half of the night in the mutant flies. The nighttime sleep is more consolidated than that of controls, with the mutant flies showing fewer sleep bouts of longer duration. The defects are more severe in the hemizygous Dh31KG09001/Df(2L)Exel7038 flies than the homozygous Dh31KG09001 flies.

      The sleep-suppressing effect of carbamazepine is strongly attenuated in homozygous flies compared to controls.

      Dh31KG09001/Dh31KG09001 and Dh31KG09001/Df(2L)Exel7038 flies have free-running circadian rhythms with a strength and period indistinguishable from controls.

      (Kunst et al., 2014)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The suppression of total nighttime sleep caused by expression of PdfScer\UAS.ML.T:SS-trypsin.T:Hsap\MYC.T:GPI-lynx1 under the control of Scer\GAL4GMR18H11 is abolished in a Dh31KG09001 homozygous background, although there remains a small, statistically significant decrease in sleep during the second half of the night.

      (Kunst et al., 2014)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      Dh31KG09001 is rescued by Scer\GAL4GMR18H11/Dh31UAS.cKa

      (Kunst et al., 2014)

      Dh31KG09001 is rescued by Dh31UAS.cKa/Scer\GAL4GMR20A02

      (Kunst et al., 2014)
      Comments

      Expression of Dh31Scer\UAS.cKa under the control of either Scer\GAL4GMR18H11 or Scer\GAL4GMR20A02 rescues waking during the 3 hours before dawn in homozygous Dh31KG09001 flies.

      (Kunst et al., 2014)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      DH31KG09001
      (Kunst et al., 2014)
      Dh31KG09001
      (Lyu et al., 2023, Lin et al., 2022, Ma et al., 2020, Lajeunesse et al., 2010)
      Dh31KG0901
      (Elya et al., 2023)
      Name Synonyms
      Secondary FlyBase IDs
        References (7)