FlyBase Allele Report: Dmel\sotv[1.8.1]

General Information

Symbol

Dmel\sotv^1.8.1

Species

D. melanogaster

Name

FlyBase ID

FBal0160487

Feature type

allele

Associated gene

Dmel\sotv

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Bornemann et al., 2004)

Progenitor genotype

Cytology

Description

Amino acid replacement: W184term.

(Bornemann et al., 2004)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

2R:16,148,107..16,148,107 [-]

Nucleotide change:

G16148107A

Amino acid change:

W184term | sotv-PB

Reported amino acid change:

W189term

Comment:

G to A nucleotide change at the second or third position of the Trp codon leads to a nonsense mutation (exact site of mutation unspecified). Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Bornemann et al., 2004)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

segment polarity phenotype | germline clone | rescuable maternal effect (with Df(2R)Jp6)

(Bornemann et al., 2004)

Phenotype Manifest In

Detailed Description

Statement

Reference

Ext2^1.8.1/Df(2R)Jp6 embryos from Ext2^1.8.1 germ line clone females fail to hatch. The resulting mature embryonic cuticles indicate a strong segment polarity phenotype: naked cuticle is largely absent, and instead the ventral surface of the cuticle is covered by a near contiguous lawn of denticles. Wings carrying clones of Ext2^1.8.1 homozygous cells have veination defects effecting veins L3 and L4, notching of the anterior wing margin and ectopic bristles in the vicinity of the wing margin. These ectopic bristles sometimes occur in adjacent heterozygous or wild-type cells. Ext2^1.8.1/Df(2R)Jp6 third instar larvae contain minute levels of heparin sulphate compared to wild-type. However, levels of chondroitin sulphate are only modestly reduced.

(Bornemann et al., 2004)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

sotv^1.8.1, ttv^00681b has abnormal immune response phenotype

(Baron et al., 2009)

Phenotype Manifest In

NOT Enhanced by

Statement

Reference

sotv^1.8.1 has wing margin bristle | ectopic | cell non-autonomous | somatic clone phenotype, non-enhanceable by ttv⁰²⁰⁵⁵/ttv⁰²⁰⁵⁵

(Bornemann et al., 2004)

sotv^1.8.1 has wing margin bristle | ectopic | somatic clone phenotype, non-enhanceable by ttv⁰²⁰⁵⁵/ttv⁰²⁰⁵⁵

(Bornemann et al., 2004)

sotv^1.8.1 has wing margin | somatic clone phenotype, non-enhanceable by ttv⁰²⁰⁵⁵/ttv⁰²⁰⁵⁵

(Bornemann et al., 2004)

sotv^1.8.1 has wing vein L4 | somatic clone phenotype, non-enhanceable by ttv⁰²⁰⁵⁵/ttv⁰²⁰⁵⁵

(Bornemann et al., 2004)

sotv^1.8.1 has wing vein L3 | somatic clone phenotype, non-enhanceable by ttv⁰²⁰⁵⁵/ttv⁰²⁰⁵⁵

(Bornemann et al., 2004)

NOT Enhancer of

Statement

Reference

sotv^1.8.1/sotv^1.8.1 is a non-enhancer of embryonic/first instar larval cuticle | rescuable maternal effect | segment polarity expression pattern | germline clone phenotype of ttv⁰²⁰⁵⁵

(Bornemann et al., 2004)

sotv^1.8.1/sotv^1.8.1 is a non-enhancer of denticle | ectopic | rescuable maternal effect | germline clone phenotype of ttv⁰²⁰⁵⁵

(Bornemann et al., 2004)

sotv^1.8.1/sotv^1.8.1 is a non-enhancer of wing margin bristle | ectopic | somatic clone phenotype of ttv⁰²⁰⁵⁵

(Bornemann et al., 2004)

sotv^1.8.1/sotv^1.8.1 is a non-enhancer of wing margin | somatic clone phenotype of ttv⁰²⁰⁵⁵

(Bornemann et al., 2004)

sotv^1.8.1/sotv^1.8.1 is a non-enhancer of wing vein L3 | somatic clone phenotype of ttv⁰²⁰⁵⁵

(Bornemann et al., 2004)

sotv^1.8.1/sotv^1.8.1 is a non-enhancer of wing vein L4 | somatic clone phenotype of ttv⁰²⁰⁵⁵

(Bornemann et al., 2004)

Additional Comments

Genetic Interactions

Statement

Reference

ttv^00681b Ext2^1.8.1 double heterozygotes exhibit increased median survival time compared to controls when infected with group B Streptococcus (both wild-type and GAG-binding impaired mutants) and lower colony counts after infection.

(Wang et al., 2011)

ttv^00681b Ext2^1.8.1 double heterozygotes exhibit reduced susceptibility to infection with the A909 strain of group B streptococcus.

(Baron et al., 2009)

The wing phenotypes due to clones of Ext2^1.8.1; ttv⁰²⁰⁵⁵ double homozygous cells are no more severe than those due to single mutant clones of either flavour.

(Bornemann et al., 2004)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Isolated in a screen for mutations lethal over Df(2R)Jp6, described in 'FBrf0129938'.

(Bornemann et al., 2004)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Ext2^1.8.1

sotv^1.8.1

(Wang et al., 2011, Baron et al., 2009)

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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