FB2024_03 , released June 25, 2024
Allele: Dmel\γTub23Cbmps1
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General Information
Symbol
Dmel\γTub23Cbmps1
Species
D. melanogaster
Name
FlyBase ID
FBal0157552
Feature type
allele
Associated gene
Dmel\γTub23C
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Mahoney et al., 2006, Parks, 2004.5.6)
Progenitor genotype
Cytology
Description

Amino acid replacement: M382I.

(Mahoney et al., 2006, Parks, 2004.5.6)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2L:2,974,322..2,974,322 [+]
Nucleotide change:

G2974322H

Amino acid change:

M382I | gammaTub23C-PA

Reported amino acid change:

M382I

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Parks, 2004.5.6)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Heterozygous pupal wings can have more or less than the wild type number (four) of neuronal cell bodies along the third wing vein and they may be spaced incorrectly.

      Heterozygous adults show a very mild rough eye phenotype that is not highly penetrant.

      At 18oC, 10% of heterozygous flies have bumps on the wing, at 23oC, the penetrance of the phenotype is 6%, while at 27oC, 92% display these bumps on the wing.

      (Mahoney et al., 2006)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      NOT suppressed by
      Statement
      Reference

      γTub23Cbmps1/γTub23CPl-2 has lethal phenotype, non-suppressible by Grip91su(Pl)

      (Vázquez et al., 2008)

      γTub23Cbmps1/γTub23CA14-9 has lethal phenotype, non-suppressible by Grip91su(Pl)

      (Vázquez et al., 2008)
      Other
      Statement
      Reference

      γTub23Cbmps1, Psn143 has visible phenotype

      (Mahoney et al., 2006)

      γTub23Cbmps1, Psn143/Psn[+] has visible phenotype

      (Mahoney et al., 2006)
      Phenotype Manifest In
      Other
      Statement
      Reference

      γTub23Cbmps1, Psn143 has eye phenotype

      (Mahoney et al., 2006)

      γTub23Cbmps1, Psn143/Psn[+] has wing blade phenotype

      (Mahoney et al., 2006)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      γTub23Cbmps1 ; Psn143/+ flies have bumps and notching on the wing.

      (Mahoney et al., 2006)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer

      Separable from: l(1)dd4su(Pl).

      (Vázquez et al., 2008)

      The l(1)dd4su(Pl) mutation was found in the γTub23Cbmps1 stock.

      (Vázquez et al., 2008)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      bmps1
      (Mahoney et al., 2006)
      γTub23Cbmps1
      (Nguyen et al., 2014, Vázquez et al., 2008)
      Name Synonyms
      Secondary FlyBase IDs
        References (4)