l(1)dd42 males can reach late pupal stages but never eclose and their discs are also degenerated. Mutant larval brains have a mitotic index approximately 6 times that of wild-type with about a third of these exhibiting a polyploid metaphase. In mutant mitotic cells spindles show abnormal centrosomes. Various centrosomal components show varied and abnormal organisation. The γ-tubulin localisation normally seen as the γ-tubulin ring complex is dispersed, cnn localisation remains in discrete bodies but often appears more broadly distributed than in wild-type. The normal juxtaposition of asp and γ-tubulin is no longer seen in mutant spindles and asp is now distributed in a punctate fashion. Cp190 is lost from the poles and accumulates around chromosomes.
Grip912/Grip91su(Pl) is a suppressor of lethal phenotype of γTub23Cbmps1/γTub23CA6-2
The slight increase in lymph gland size seen in Zfrp8SM206/+ larvae is dominantly enhanced by l(1)dd42.
Carpenter.
l(1)dd4 mutations can be placed in an allelic series based on relative severity of phenotype: l(1)dd4S < l(1)dd42 = l(1)dd4xr16 l(1)dd41 < Df(1)LCD.