FB2024_03 , released June 25, 2024
Allele: Dmel\Ptp69D7
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General Information
Symbol
Dmel\Ptp69D7
Species
D. melanogaster
Name
FlyBase ID
FBal0152273
Feature type
allele
Associated gene
Dmel\Ptp69D
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Desai and Purdy, 2003)
Progenitor genotype
Cytology
Description

9bp deletion, deleting amino acids 1065-1067.

(Desai and Purdy, 2003)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
3L:12,739,430..12,739,438 [+]
Comment:

Reported as a 9bp deletion that removes amino acid residues 1065-1067. Position of mutation on reference sequence inferred by FlyBase curator.

(Desai and Purdy, 2003)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygotes do not form pupae at either 18 or 25oC. Ptp69D7 embryos show motor axon defects; 57% of ISNb axons, 27% of ISN axons, 24% of SNa axons and 26% of SNc axons show defects. 25% of ISNb axons show a complete bypass phenotype and 15% show a partial bypass phenotype.

      (Desai and Purdy, 2003)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Statement
      Reference

      Ptp69D7 has abnormal neuroanatomy phenotype, suppressible by Ptp99A[+]/Ptp99A1

      (Desai and Purdy, 2003)
      NOT Enhancer of
      Statement
      Reference

      Ptp69D[+]/Ptp69D7 is a non-enhancer of abnormal neuroanatomy | embryonic stage phenotype of cknK.Δ324-331

      (Weng et al., 2011)
      NOT Suppressor of
      Statement
      Reference

      Ptp69D[+]/Ptp69D7 is a non-suppressor of abnormal neuroanatomy | embryonic stage phenotype of cknK.Δ324-331

      (Weng et al., 2011)
      Phenotype Manifest In
      Suppressed by
      Statement
      Reference

      Ptp69D7 has larval intersegmental nerve phenotype, suppressible by Ptp99A[+]/Ptp99A1

      (Desai and Purdy, 2003)
      NOT Enhancer of
      Statement
      Reference

      Ptp69D[+]/Ptp69D7 is a non-enhancer of larval intersegmental nerve | embryonic stage phenotype of cknK.Δ324-331

      (Weng et al., 2011)

      Ptp69D[+]/Ptp69D7 is a non-enhancer of larval intersegmental nerve branch ISNb of A1-7 | embryonic stage phenotype of cknK.Δ324-331

      (Weng et al., 2011)
      NOT Suppressor of
      Statement
      Reference

      Ptp69D[+]/Ptp69D7 is a non-suppressor of larval intersegmental nerve | embryonic stage phenotype of cknK.Δ324-331

      (Weng et al., 2011)

      Ptp69D[+]/Ptp69D7 is a non-suppressor of larval intersegmental nerve branch ISNb of A1-7 | embryonic stage phenotype of cknK.Δ324-331

      (Weng et al., 2011)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      A heterozygous or homozygous Ptp69D7 background fails to affect the penetrance of the ISNb bypass phenotype found in cknK.Δ324-331 heterozygotes or homozygotes.

      (Weng et al., 2011)

      The ISNb bypass phenotype seen in Ptp69D7 homozygous embryos is largely suppressed by one copy of Ptp99A1.

      (Desai and Purdy, 2003)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Ptp69D7
      (Weng et al., 2011)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)