FB2024_03 , released June 25, 2024
Allele: Dmel\sdFab-X
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General Information
Symbol
Dmel\sdFab-X
Species
D. melanogaster
Name
FlyBase ID
FBal0151504
Feature type
allele
Associated gene
Dmel\sd
Associated Insertion(s)
P{UAS-lacZ.Abd-B.5F24}25,2a
P{UAS-lacZ.Abd-B.5F24}25,2b
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Bantignies et al., 2003)
Progenitor genotype
Associated Insertion(s)
P{UAS-lacZ.Abd-B.5F24}25,2a
P{UAS-lacZ.Abd-B.5F24}25,2b
Cytology
Description

Contains two copies of the P{UAS-lacZ.Abd-B.5F24} transgene inserted in tandem 9.9kb upstream of the sd gene.

(Bantignies et al., 2003)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      sdFab-X homozygous adults exhibit disrupted wing morphology.

      (Fresán et al., 2020)

      sdFab-X homozygotes exhibit stumpy wings.

      (Dutta and Li, 2017)

      sdFab-X flies show a strong crumpled wing phenotype when raised at 28.5oC.

      (Grimaud et al., 2006)

      16% of homozygous females show wing blade destruction in one wing, and 72% show wing blade destruction in both wings.

      (Canudas et al., 2005)

      Hemizygotes and heterozygotes have wild-type wing, but 95% of homozygotes have a display a destruction of the wing blade.

      (Bantignies et al., 2003)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Statement
      Reference

      sdFab-X has visible | recessive phenotype, suppressible | partially by tara1/tara[+]

      (Dutta and Li, 2017)

      sdFab-X has visible | recessive phenotype, suppressible by Df(3R)sbd45/Bin1R7-18

      (Canudas et al., 2005)

      sdFab-X has visible | recessive phenotype, suppressible by Bin1[+]/Bin1R7-18

      (Canudas et al., 2005)

      sdFab-X has visible | recessive phenotype, suppressible by HDAC1def24/Rpd3[+]

      (Canudas et al., 2005)

      sdFab-X has visible | recessive phenotype, suppressible by Trl[+]/TrlR67

      (Canudas et al., 2005)
      Phenotype Manifest In
      Enhanced by
      Statement
      Reference

      sdFab-X has wing phenotype, enhanceable by trxE2

      (Bantignies et al., 2003)
      Suppressed by
      Statement
      Reference

      sdFab-X has wing phenotype, suppressible | partially by Haspin128

      (Fresán et al., 2020)

      sdFab-X has wing phenotype, suppressible | partially by tara1/tara[+]

      (Dutta and Li, 2017)

      sdFab-X has wing phenotype, suppressible by AGO172/AGO145

      (Grimaud et al., 2006)

      sdFab-X has wing phenotype, suppressible by Dcr-2L811fsX/Dcr-2L811fsX

      (Grimaud et al., 2006)

      sdFab-X has wing phenotype, suppressible by piwi1

      (Grimaud et al., 2006)

      sdFab-X has wing phenotype, suppressible by piwi2

      (Grimaud et al., 2006)

      sdFab-X has wing blade phenotype, suppressible by Df(3R)sbd45/Bin1R7-18

      (Canudas et al., 2005)

      sdFab-X has wing blade phenotype, suppressible by Bin1[+]/Bin1R7-18

      (Canudas et al., 2005)

      sdFab-X has wing blade phenotype, suppressible by HDAC1def24/Rpd3[+]

      (Canudas et al., 2005)

      sdFab-X has wing blade phenotype, suppressible by Trl[+]/TrlR67

      (Canudas et al., 2005)

      sdFab-X has wing phenotype, suppressible by Fab-71

      (Bantignies et al., 2003)

      sdFab-X has wing phenotype, suppressible by Pcl10

      (Bantignies et al., 2003)

      sdFab-X has wing phenotype, suppressible by Psc1

      (Bantignies et al., 2003)

      sdFab-X has wing phenotype, suppressible by ph-p410

      (Bantignies et al., 2003)

      sdFab-X has wing phenotype, suppressible by Pc11

      (Bantignies et al., 2003)
      NOT suppressed by
      Statement
      Reference

      sdFab-X has wing phenotype, non-suppressible by spn-Ehls-E1

      (Grimaud et al., 2006)

      sdFab-X has wing phenotype, non-suppressible by Dcr-1Q1147X/Dcr-1[+]

      (Grimaud et al., 2006)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The wing phenotype of sdFab-X flies is suppressed in the following double mutant genotypes: sdFab-X;AGO172/AGO145, sdFab-X;Dcr-2L811fsX, sdFab-X;piwi1 and sdFab-X;piwi2. However, this phenotype is not suppressed in the following double mutants: sdFab-X;spn-Ehls-E1, sdFab-X;Dcr-1Q1147X/+.

      (Grimaud et al., 2006)

      The wing blade destruction phenotype of homozygous sdFab-X females is strongly suppressed by Bin1R7-18/Df(3R)sbd45 : 13% of the double mutants show wing blade destruction in one wing, and 4% show wing blade destruction in both wings.

      The wing blade destruction phenotype of homozygous sdFab-X females is significantly suppressed by Bin1R7-18/+ (39% show wing blade destruction in one wing, 36% show wing blade destruction in both wings), Rpd3def24/+ (26% show wing blade destruction in one wing, 30% show wing blade destruction in both wings) or TrlR67/+ (32% show wing blade destruction in one wing, 51% show wing blade destruction in both wings).

      (Canudas et al., 2005)

      The addition of Fab-71 suppresses the wing phenotype seen in sdFab-X animals. The addition of additional insertions of the P{UAS-lacZ.Abd-B.5F24} transgene (P{UAS-lacZ.Abd-B.5F3}22,51 or P{UAS-lacZ.Abd-B.5F24}21,17) represses this suppression allowing the wing phenotype to manifest again. The addition of P{Mcp-w#11}45 or P{UAS-lacZ.U/l5}1,1 does not have this effect.

      (Bantignies et al., 2003)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Fab-X
      (Grimaud et al., 2006)
      sdFab-X
      Name Synonyms
      Secondary FlyBase IDs
        References (6)