FlyBase Allele Report: Dmel\HDAC1[def24]

General Information

Symbol

Dmel\HDAC1^def24

Species

D. melanogaster

Name

FlyBase ID

FBal0104000

Feature type

allele

Associated gene

Dmel\HDAC1

Associated Insertion(s)

Carried in Construct

Also Known As

rpd3^def24

Key Links

Allele class

loss of function allele

Mutagen

Delta2-3 transposase

Nature of the Allele

Allele class

loss of function allele

(Rogina et al., 2002, Mottus et al., 2000)

Mutagen

Delta2-3 transposase

(Mottus et al., 2000)

Progenitor genotype

HDAC1⁰⁴⁵⁵⁶

(Mottus et al., 2000)

Cytology

Description

Deletion beginning at insertion point of P{PZ} in Rpd3⁰⁴⁵⁵⁶ and extends to the amino terminal coding region. Approximately 870 bp are deleted. Conceptual translation of the remaining polypeptide suggests any possible peptide would bear no similarity to the wild type Rpd3 gene product.

(Mottus et al., 2000)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Schimke immuno-osseous dysplasia

modeled by Marcal1^UAS.cBa

(Morimoto et al., 2016)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | somatic clone

(Tea et al., 2010)

enhancer of variegation, with P{UAS-lacZ.Abd-B.24F6}GCD-6/+:

(Canudas et al., 2005)

lethal - all die before end of larval stage | recessive

(Mottus et al., 2000)

long lived

(Rogina and Helfand, 2004)

long lived | dominant | male

(Rogina et al., 2002)

some die during larval stage | recessive

(Mottus et al., 2000)

Phenotype Manifest In

adult antennal lobe projection neuron DL1 adPN | somatic clone

(Tea et al., 2010)

Detailed Description

Statement

Reference

Homozygous single-cell DL1 projection neuron clones mistarget their dendrites towards dorsomedial (61% of clones) or ventromedial regions (25% of clones) of the antennal lobe (normally the dendrites of this projection neuron project to the dorsolateral glomerulus DL1).

(Tea et al., 2010)

Rpd3^def24/+ flies have a normal number of dorsocentral bristles.

(Biryukova and Heitzler, 2008)

Rpd3^def24/+ enhances the silencing of the w marker gene which is seen in the P{UAS-lacZ.Abd-B.24F6}GCD-6 insertion, such that the eye is less pigmented in the presence of Rpd3^def24/+.

(Canudas et al., 2005)

The average lifespan of Rpd3^def24 homozygous flies is longer than wild-type.

(Rogina and Helfand, 2004)

Heterozygous males show a 41% (maternally derived Rpd3^def24 allele) or 47% (paternally derived Rpd3^def24 allele) extension of life-span. Heterozygous females have only modest changes in life-span; maximum but not median life-spans are increased.

(Rogina et al., 2002)

Lethality principally affects the third larval instar stage.

(Mottus et al., 2000)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

HDAC1^def24 has long lived phenotype, suppressible by Sirt1¹⁷/Sir2[+]

(Rogina and Helfand, 2004)

HDAC1^def24 has long lived phenotype, suppressible by Sirt1^EP2300/Sir2[+]

(Rogina and Helfand, 2004)

Suppressor of

Statement

Reference

HDAC1^def24/Rpd3[+] is a suppressor of visible | recessive phenotype of sd^Fab-X

(Canudas et al., 2005)

HDAC1^def24, Scer\GAL4^DJ651 is a suppressor of short lived phenotype of Ctet\tetX^TNT-LC.UAS, Scer\GAL4^DJ651

(Bauer et al., 2004)

Other

Statement

Reference

Df(3R)sbd45/+, HDAC1^def24 has visible | dominant phenotype

(Canudas et al., 2005)

Phenotype Manifest In

Enhancer of

Statement

Reference

HDAC1^def24/Rpd3[+] is an enhancer of dorsocentral bristle | increased number phenotype of pnr^D1

(Biryukova and Heitzler, 2008)

Suppressor of

Statement

Reference

HDAC1^def24/Rpd3[+] is a suppressor of wing blade phenotype of sd^Fab-X

(Canudas et al., 2005)

Other

Statement

Reference

Df(3R)sbd45/+, HDAC1^def24 has adult abdominal segment 6 phenotype

(Canudas et al., 2005)

Df(3R)sbd45/+, HDAC1^def24 has abdominal sternite bristle | ectopic phenotype

(Canudas et al., 2005)

Additional Comments

Genetic Interactions

Statement

Reference

Rpd3^def24/+ enhances the phenotype of pnr^D1/+, resulting in extra dorsocentral sensory organs.

(Biryukova and Heitzler, 2008)

86% of Rpd3^def24/Df(3R)sbd45 transheterozygous males show transformation of A6 to A5, as judged by the presence of at least one bristle on the sixth sternite.

Rpd3^def24/Bin1^R7-18 transheterozygous males do not show transformation of A6 to A5.

The wing blade destruction phenotype of homozygous sd^Fab-X females is significantly suppressed by Rpd3^def24/+ (26% show wing blade destruction in one wing, 30% show wing blade destruction in both wings).

(Canudas et al., 2005)

The lifespan of males expressing Ctet\TeTxLC^TNT.Scer\UAS under the control of Scer\GAL4^DJ651 is significantly extended if they also carry Rpd3^def24.

(Bauer et al., 2004)

The increased average lifespan of HDAC1^def24 homozygous flies is suppressed by Sirt1¹⁷/+ or Sirt1^EP2300/+.

(Rogina and Helfand, 2004)

Xenogenetic Interactions

Statement

Reference

The decreased lifespan of males expressing Ctet\TeTxLC^TNT.Scer\UAS under the control of Scer\GAL4^DJ651 is significantly suppressed if they also carry HDAC1^def24.

The reduced lifespan seen in males expressing Ctet\TeTxLC^TNT.Scer\UAS under the control of Scer\GAL4^DJ651 can be suppressed if the males also carry Indy²⁰⁶/+. Only a small increase in lifespan is seen in females expressing Ctet\TeTxLC^TNT.Scer\UAS under the control of Scer\GAL4^DJ651 and carrying Indy²⁰⁶/+.

(Bauer et al., 2004)

Complementation and Rescue Data

Rescued by

HDAC1^def24 is rescued by HDAC1^UAS.Tag:V5/Scer\GAL4^GH146

(Tea et al., 2010)

Comments

Expression of Rpd3^{Scer\UAS.T:SV5\V5} under the control of Scer\GAL4^GH146 in single-cell DL1 projection neuron clones which are mutant for Rpd3^def24 significantly rescues the dendrite mistargeting defects seen in these clones.

(Tea et al., 2010)

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

32239

w^*; HDAC1^def24 P{FRT(w^hs)}2A P{neoFRT}82B/TM6B, Tb¹

Notes on Origin

Discoverer

Comments

Null allele.

(Mottus et al., 2000)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

HDAC1^def24

(Biryukova and Heitzler, 2008, Mottus et al., 2000)

HDAC^def24

(Canudas et al., 2005)

Rpd3^def24

(Angulo et al., 2019, Janssens et al., 2017, Tea et al., 2010)

rpd3^Def24

(Bauer et al., 2004)

rpd3^def24

(Struffi and Arnosti, 2005, Rogina and Helfand, 2004, Rogina et al., 2002)

Name Synonyms

Secondary FlyBase IDs

References (11)

Report Sections

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