FB2024_03 , released June 25, 2024
Allele: Dmel\trold8
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General Information
Symbol
Dmel\trold8
Species
D. melanogaster
Name
FlyBase ID
FBal0143155
Feature type
allele
Associated gene
Dmel\trol
Associated Insertion(s)
Carried in Construct
Also Known As
trol8
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
diepoxybutane
(Park et al., 2003)
Progenitor genotype
Cytology
Description

Unspecified lesion in trol ORF.

(Park et al., 2003)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      trold8 mutants exhibit more compact looking imaginal discs, with sections showing elongation of cells in the apico-basal axis. in addition, the central nervous system shows signs of hyper-constriction, with vesicles of tissue herniating from the ventral nerve cord.

      (Pastor-Pareja and Xu, 2011)

      Explanted trold8/trold8 larval brains show reduced levels of neuroblast proliferation.

      (Park et al., 2003)

      23% of trold8 brains show defective larval neuroblast proliferation.

      (Park et al., 2001)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhanced by
      Statement
      Reference

      trold8 has decreased occurrence of cell division | larval stage phenotype, enhanceable by eve3/eve[+]

      (Park et al., 2001)
      Other
      Phenotype Manifest In
      Enhanced by
      Statement
      Reference

      trold8 has neuroblast | larval stage phenotype, enhanceable by hh2

      (Park et al., 2003)

      trold8 has neuroblast | larval stage phenotype, enhanceable by hhAC

      (Park et al., 2003)

      trold8 has larval brain & neuroblast phenotype, enhanceable by eve3/eve[+]

      (Park et al., 2001)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      trold8/trold8; larvae, heterozygous for hh2or hhAC have reduced numbers S phase neuroblasts per brain lobe compared to trold8 homozygotes.

      (Park et al., 2003)

      The proliferation defect seen in trold8 animals is enhanced by one copy of eve3; 88% of animals show defective proliferation.

      (Park et al., 2001)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Dimlich & Kankel

      (Park et al., 2003)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      trol8
      (Grigorian et al., 2013, Pastor-Pareja and Xu, 2011, Park et al., 2001)
      trold8
      Name Synonyms
      Secondary FlyBase IDs
        References (4)