FlyBase Allele Report: Dmel\hh[2]

General Information

Symbol

Dmel\hh²

Species

D. melanogaster

Name

FlyBase ID

FBal0005463

Feature type

allele

Associated gene

Dmel\hh

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Tearle and Nusslein-Volhard, 1987)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates multiple endocrine neoplasia type 2B

modeled by Ret^MEN2B.GMR

(Read et al., 2005)

exacerbates multiple endocrine neoplasia type 2A

modeled by Ret^MEN2A.GMR

(Read et al., 2005)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal size | adult stage (with hh^bar3)

(Wang et al., 2017)

abnormal size | adult stage (with hh^Mrt)

(Wang et al., 2017)

abnormal size | adult stage (with hh^ΔaptDB1)

(Wang et al., 2017)

lethal - all die during embryonic stage | recessive

segment polarity phenotype | embryonic stage | recessive

some die during embryonic stage | recessive

visible (with hh^bar3)

(Wang et al., 2017)

visible (with hh^Mrt)

(Wang et al., 2017)

visible (with hh^ΔaptDB1)

(Wang et al., 2017)

Phenotype Manifest In

2nd posterior cell

(Palsson and Gibson, 2000)

crossvein | ectopic (with hh^bar3)

(Wang et al., 2017)

crossvein | ectopic (with hh^Mrt)

(Wang et al., 2017)

crossvein | ectopic (with hh^ΔaptDB1)

(Wang et al., 2017)

embryonic epidermis

ventral denticle belt

wing (with hh^bar3)

(Wang et al., 2017)

wing (with hh^Mrt)

(Wang et al., 2017)

wing (with hh^ΔaptDB1)

(Wang et al., 2017)

Detailed Description

Statement

Reference

hh²/hh^bar3 and hh²/hh^Mrt mutant adults both exhibit smaller wings with an ectopic crossvein, as compared to controls.

Adult wings of hh²/+ mutants appear normal.

hh^ΔaptDB1/hh² mutant adults exhibit smaller wings with an ectopic crossvein, as compared to controls.

(Wang et al., 2017)

hh²/+ larvae have normal numbers S phase neuroblasts per brain lobe.

(Park et al., 2003)

Heterozygotes show a quantitative effect on wing shape in intervein region D compared to wild type.

(Palsson and Gibson, 2000)

Coordinate mutant.

(Sturtevant and Bier, 1995)

Weak phenotype. Mutant embryos show fusions that delete the naked cuticle usually between abdominal segments 1 and 2 and 6, 7 and 8.

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

hh² is an enhancer of visible phenotype of Ret^MEN2B.GMR

(Read et al., 2005)

hh² is an enhancer of visible phenotype of Ret^MEN2A.GMR

(Read et al., 2005)

Suppressor of

Statement

Reference

hh[+]/hh² is a suppressor of increased cell number | oogenesis phenotype of Scer\GAL4^C587, Su(var)3-3^NIG.17149R

(Eliazer et al., 2014)

Other

Statement

Reference

CycE^JP, hh[+]/hh² has visible phenotype

(Wang et al., 2017)

apt^tdf-PΔ4/apt[+], hh² has visible phenotype

(Wang et al., 2017)

apt^tdf-PΔ4/apt[+], hh² has abnormal size | adult stage phenotype

(Wang et al., 2017)

hh[+]/hh², trol¹³ has decreased occurrence of cell division | larval stage phenotype

(Park et al., 2003)

hh[+]/hh², trol^d8 has decreased occurrence of cell division | larval stage phenotype

(Park et al., 2003)

Phenotype Manifest In

Enhancer of

Statement

Reference

hh² is an enhancer of eye phenotype of Ret^MEN2B.GMR

(Read et al., 2005)

hh² is an enhancer of eye phenotype of Ret^MEN2A.GMR

(Read et al., 2005)

hh[+]/hh² is an enhancer of neuroblast | larval stage phenotype of trol¹³

(Park et al., 2003)

hh² is an enhancer of neuroblast | larval stage phenotype of trol^d8

(Park et al., 2003)

hh² is an enhancer of pigment cell phenotype of sgl⁰⁵⁰⁰⁷, w^a

(Benevolenskaya et al., 1998)

Suppressor of

Statement

Reference

hh[+]/hh² is a suppressor of egg chamber | decreased number phenotype of Scer\GAL4^C587, Su(var)3-3^NIG.17149R

(Eliazer et al., 2014)

Other

Statement

Reference

CycE^JP, hh[+]/hh² has wing phenotype

(Wang et al., 2017)

CycE^JP, hh[+]/hh² has crossvein | ectopic phenotype

(Wang et al., 2017)

apt^tdf-PΔ4/apt[+], hh² has wing phenotype

(Wang et al., 2017)

apt^tdf-PΔ4/apt[+], hh² has crossvein | ectopic phenotype

(Wang et al., 2017)

Additional Comments

Genetic Interactions

Statement

Reference

hh²/+, apt^tdf-PΔ4/+ double mutant adults exhibit smaller wings with an ectopic crossvein, as compared to controls.

A subset of CycE^JP/+, hh²/+ double mutant flies exhibit wings with an ectopic crossvein.

(Wang et al., 2017)

trol¹³/trol¹³; hh²/+ larvae have reduced numbers S phase neuroblasts per brain lobe compared to trol¹³ homozygotes. trol^d8/trol^d8; hh²/+ larvae have reduced numbers S phase neuroblasts per brain lobe compared to trol^d8 homozygotes.

(Park et al., 2003)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

3376

st¹ e¹ hh²/TM3, Sb¹ Ser¹

Kyoto

107020

st¹ e¹ hh²/TM3, Sb¹

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

hh²

(Wang et al., 2017, Eliazer et al., 2014, Watson et al., 2011, Chanana et al., 2007, Chu et al., 2006, Guichard et al., 2006)

hh^6L

(Tearle and Nusslein-Volhard, 1987)

Name Synonyms

Secondary FlyBase IDs

References (15)

Report Sections

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