FlyBase Allele Report: Dmel\Mekk1[Ur36]

General Information

Symbol

Dmel\Mekk1^Ur36

Species

D. melanogaster

Name

FlyBase ID

FBal0141666

Feature type

allele

Associated gene

Dmel\Mekk1

Associated Insertion(s)

Carried in Construct

Also Known As

dMekk1^Ur36

Key Links

Allele class

amorphic allele - molecular evidence

Mutagen

P-element activity

Nature of the Allele

Allele class

amorphic allele - molecular evidence

(Schoborg et al., 2013)

Mutagen

P-element activity

(Inoue et al., 2001)

Progenitor genotype

Mekk1^S028102a

(Inoue et al., 2001)

Cytology

Description

Deletion of the P{lacW} of the progenitor allele and 868 bp of flanking DNA, removing amino acids 1194-1483. The deleted section includes the kinase subdomain I-IX.

(Inoue et al., 2001)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates retinal disease

modeled by ninaE^G69D.UAS

(Kang et al., 2012)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

embryonic/larval hindgut | larval stage | posterior

(Seisenbacher et al., 2011)

embryonic/larval hindgut | larval stage | posterior | nutrition conditional

(Seisenbacher et al., 2011)

Detailed Description

Statement

Reference

Mekk1^Ur36 mutant flies accumulate lipids in the midgut.

(Chakrabarti et al., 2014)

Mutant flies are more resistant to tunicamycin compared to controls.

(Kang et al., 2012)

Mekk1^Ur36 mutant larvae exhibit a melanotic phenotype under normal food conditions. A "black dot" is seen in the posterior hindgut. The phenotype is exacerbated in response to salt stress.

(Seisenbacher et al., 2011)

Mekk1^Ur36 heterozygotes show enhanced w silencing in the In(1)w^m4 line.

In contrast to controls, Mekk1^Ur36 mutant flies do not show relieved w silencing in the In(1)w^m4 line when embryos are exposed to heat-shock 0-3 hours after egg laying.

(Seong et al., 2011)

Mutant flies show normal levels of survival after infection after infection with E.coli, E.faecalis or A.fumigatus.

Homozygous flies show a strong increase in sensitivity to oxidative stress induced by paraquat compared to controls.

(Brun et al., 2006)

Shows increased susceptibility to high osmolarity (0.2M NaCl). Effect less pronounced than reported in FBrf0139644. No immune reponse deficiency could be detected. Response to bacterial infection was not compromised. Wound healing appears normal.

(Craig et al., 2004)

Homozygotes and hemizygotes show no obvious morphological abnormalities. Response to heat stress and osmotic stress is defective. Viability of mutants relative to wild type is reduced by 20% at 30^oC. Mutants die before eclosion when raised on 0.2M NaCl.

(Inoue et al., 2001)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Mekk1^Ur36/Mekk1[+] is an enhancer of visible phenotype of Rala^35d

(Balakireva et al., 2006)

Suppressor of

Statement

Reference

Mekk1^Ur36/Mekk1^Ur36 is a suppressor of increased cell death phenotype of Scer\GAL4^GMR.PF, ninaE^G69D.UAS

(Kang et al., 2012)

Mekk1^Ur36/Mekk1^Ur36 is a suppressor of visible phenotype of Scer\GAL4^GMR.PF, ninaE^G69D.UAS

(Kang et al., 2012)

Phenotype Manifest In

Enhancer of

Statement

Reference

Mekk1^Ur36/Mekk1[+] is an enhancer of microchaeta phenotype of Rala^35d

(Balakireva et al., 2006)

Mekk1^Ur36/Mekk1[+] is an enhancer of macrochaeta phenotype of Rala^35d

(Balakireva et al., 2006)

Suppressor of

Statement

Reference

Mekk1^Ur36/Mekk1^Ur36 is a suppressor | partially of retina | conditional phenotype of ninaE^G69D

(Kang et al., 2012)

Mekk1^Ur36/Mekk1^Ur36 is a suppressor of eye phenotype of Scer\GAL4^GMR.PF, ninaE^G69D.UAS

(Kang et al., 2012)

Mekk1^Ur36/Mekk1^Ur36 is a suppressor of eye disc phenotype of Scer\GAL4^GMR.PF, ninaE^G69D.UAS

(Kang et al., 2012)

Additional Comments

Genetic Interactions

Statement

Reference

Mekk1^Ur36/Mekk1^Ur36 partially suppresses the eye defects caused by expression of ninaE^{G69D.Scer\UAS} under the control of Scer\GAL4^GMR.PF. The massive apoptosis seen in the larval eye discs of animals expressing ninaE^{G69D.Scer\UAS} under the control of Scer\GAL4^GMR.PF is suppressed by Mekk1^Ur36/Mekk1^Ur36.

The time course of retinal degeneration seen in ninaE^G69D/+ flies is delayed in a Mekk1^Ur36/Mekk1^Ur36 background.

(Kang et al., 2012)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Mekk1^Ur36 is rescued by Mekk1^hs.PI

(Inoue et al., 2001)

Partially rescued by

Mekk1^Ur36 is partially rescued by Mekk1^hs.PI

(Brun et al., 2006)

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

81036

w^*; P{neoFRT}82B Mekk1^Ur36/TM3, Sb¹

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (10)

Reported As

Symbol Synonym

D-MEKK1^Ur36

(Craig et al., 2004)

MEKK1^Ur36

(Lee et al., 2013, Seisenbacher et al., 2011, Ha et al., 2009)

Mekk1^Ur36

(Seong et al., 2020, Nelson et al., 2016, Chakrabarti et al., 2014, Brun et al., 2006)

Mekk1^ur36

(Li et al., 2020)

dMEKK1^Ur3

(Chakrabarti et al., 2012)

dMeKK1^UR36

(Schoborg et al., 2013)

dMekk1^Ur36

(Seong et al., 2011, Shimizu et al., 2008)

dMekk1^ur36

(Seong et al., 2011)

mekk1^Ur36

(Balakireva et al., 2006)

mekk1^ur-36

(Kang et al., 2012)

Name Synonyms

Secondary FlyBase IDs

References (17)

Report Sections

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