FB2024_03 , released June 25, 2024
Allele: Dmel\Rab11ex2
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General Information
Symbol
Dmel\Rab11ex2
Species
D. melanogaster
Name
FlyBase ID
FBal0135840
Feature type
allele
Associated gene
Dmel\Rab11
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
Delta2-3 transposase
(Dollar et al., 2002)
Progenitor genotype
Rab11j2D1
(Dollar et al., 2002)
Cytology
Description

Imprecise excision of the P{lacW} insertion in Rab11j2D1 has created a deletion that removes the second intron of the Rab11 gene.

(Dollar et al., 2002)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      While homozygous mutant Rab11ex2 R-cell clones still project processes that attach to the apical surface and correctly send axons basally, many R-cell nuclei appear abnormally at the basal side.

      (Houalla et al., 2010)

      Rab11ex2/+ flies show no eye phenotype.

      (Khodosh et al., 2006)

      Oogenesis is arrested before oocyte determination in Rab11ex1 germ-line clones.

      (Dollar et al., 2002)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      Rab11ex2/Rab11[+] is an enhancer of eye phenotype of RN-treUAS.cHa, Scer\GAL4GMR.long

      (Houalla et al., 2010)

      Rab11ex2/Rab11[+] is an enhancer of eye phenotype of Scer\GAL4GMR.PF, bchsEP2299

      (Khodosh et al., 2006)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Reducing the dosage of Rab11 through a Rab11ex2 heterozygous background significantly enhances the RN-treScer\UAS.cHa-induced rough eye phenotype.

      (Houalla et al., 2010)

      Rab11ex2 heterozygotes act as dominant enhancers of the Scer\GAL4GMR.PF>bchsEP2299 eye phenotype, resulting in adults with severely reduced eyes.

      (Khodosh et al., 2006)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      Rab11j2D1

      (Dollar et al., 2002)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Rab11ex2
      (Houalla et al., 2010)
      rab11ex2
      (Walsh et al., 2021, Khodosh et al., 2006)
      Name Synonyms
      Secondary FlyBase IDs
        References (4)