FlyBase Allele Report: Dmel\sti[KG01697]

General Information

Symbol

Dmel\sti^KG01697

Species

D. melanogaster

Name

FlyBase ID

FBal0131723

Feature type

allele

Associated gene

Dmel\sti

Associated Insertion(s)

P{SUPor-P}sti^KG01697

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Gene Disruption Project members, 2001-)

Progenitor genotype

Associated Insertion(s)

P{SUPor-P}sti^KG01697

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

3L:12,514,787..12,514,787 [+]

(Naim et al., 2004, Gene Disruption Project members, 2001-)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal cytokinesis

(Naim et al., 2004)

lethal | pupal stage

(Shandala et al., 2004)

lethal | pupal stage (with Df(3L)iro-2)

(Shandala et al., 2004)

lethal | pupal stage (with sti^GS9053)

(Shandala et al., 2004)

partially lethal - majority die | larval stage

(Shandala et al., 2004)

partially lethal - majority die | larval stage (with Df(3L)iro-2)

(Shandala et al., 2004)

partially lethal - majority die | larval stage (with sti^GS9053)

(Shandala et al., 2004)

Phenotype Manifest In

presumptive embryonic/larval peripheral nervous system (with Df(3L)iro-2)

(Shandala et al., 2004)

Detailed Description

Statement

Reference

The brains of sti^KG01697/Df(3L)E44 mutants have higher levels of polyploid cells than wild-type brains. However, the chromosomes of these cells are morphologically normal and the mitotic index is similar to wild type.

(Naim et al., 2004)

Stage 16 sti^KG01697/Df(3L)iro-2 embryos have a modestly disrupted peripheral nervous system with some disorganisation of clusters and defects in axonal projections. In about 15 % of these embryos there is a loss of neurons and concomitant appearance of binucleate neurons.

(Shandala et al., 2004)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Enhancer of

Statement

Reference

sti^KG01697/sti[+] is an enhancer of wing hair | increased number phenotype of Scer\GAL4^en-e16E, pbl^RNAi.UAS

(Shandala et al., 2004)

sti^KG01697/sti[+] is an enhancer of wing blade posterior compartment phenotype of Scer\GAL4^en-e16E, pbl^RNAi.UAS

(Shandala et al., 2004)

Additional Comments

Genetic Interactions

Statement

Reference

The reduction in compartment size and the percentage of cells with multiple wing hairs in pbl^{dsRNA.Scer\UAS}; Scer\GAL4^en-e16E flies are both enhanced by sti^KG01697/+.

(Shandala et al., 2004)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

sti^dck2

(Naim et al., 2004)

sti¹

(Naim et al., 2004)

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

13471

y¹; P{SUPor-P}sti^KG01697 ry⁵⁰⁶/TM3, Sb¹ Ser¹

Kyoto

111548

y^d2 w¹¹¹⁸ P{ey-FLP.N}2 P{5xglBS-lacZ.38-1}TPN1; P{SUPor-P}sti^KG01697 P{neoFRT}80B/TM6B, P{Car20y}TPN1, Tb¹

Notes on Origin

Discoverer

Comments

Lethality over Df(3L)iro-2 is revertable with Δ2-3.

(Shandala et al., 2004)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

CG10522^KG01697

cit¹

(Shandala et al., 2004)

cit^KG01697

dck³

(Naim et al., 2004)

sti^KG01697

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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