FB2024_03 , released June 25, 2024
Allele: Dmel\Dgatu
Open Close
General Information
Symbol
Dmel\Dgatu
Species
D. melanogaster
Name
atsugari
FlyBase ID
FBal0131266
Feature type
allele
Associated gene
Dmel\Dg
Associated Insertion(s)
P{lwB}Dgatu
Carried in Construct
Key Links
Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Takeuchi et al., 2009)
Mutagen
P-element activity
(Takeuchi et al., 2009)
Progenitor genotype
Associated Insertion(s)
P{lwB}Dgatu
Cytology
Description

Insertion 251bp downstream of the transcription start site of Dg.

(Takeuchi et al., 2009)
Allele components
Component
Use(s)
Inserted element
P{lwB}
Encoded product / tool
lacZ
Tagged with
Tag:NLS(P)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Mutant animals are cryophilic (cold-seeking). Dgatu mutant larvae raised at 25[o]C show a strong temperature preference that peaks at 18.0[o]C on a linear thermal gradient ranging from 12[0] to 35[o]C, in contrast to wild-type larvae which have a temperature preference peak of 22.1[o]C in this assay.

      The cryophilic phenotype of Dgatu larvae is alleviated to some extent by administering rotenone, but not by administering tolbutamide.

      The cryophilic phenotype of Dgatu larvae is suppressed by hyperoxic conditions.

      Dgatu/DgEP2241 larvae raised at 25[o]C show a strong temperature preference that peaks at 17.6[o]C on a linear thermal gradient ranging from 12[0] to 35[o]C.

      Dgatu larvae show greater tolerance to cold temperature than wild-type larvae, although the susceptibility of the mutant larvae to high temperature is similar to that of wild type.

      Mutants show normal olfactory, visual and locomotor behaviour.

      The metabolic rate of Dgatu larvae (measured in terms of CO[[2]] production) is 1.9 times higher than that of control larvae.

      (Takeuchi et al., 2009)

      Larvae show a strong preference for low temperature.

      (Takeuchi et al., 2001)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Statement
      Reference

      Dgatu has abnormal thermotaxis | third instar larval stage phenotype, suppressible by Pdpe02351

      (Takeuchi et al., 2009)
      Suppressor of
      Statement
      Reference

      Dgatu is a suppressor of abnormal thermotaxis | third instar larval stage phenotype of Pdpe02351

      (Takeuchi et al., 2009)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Dgatu Pdpe02351 double mutant larvae raised at 25[o]C show a strong temperature preference that peaks at 22.2[o]C on a linear thermal gradient ranging from 12[0] to 35[o]C. This preferred temperature is significantly different from that of either single mutant, which is 17.9[o]C for Dgatu larvae and 23.1[o]C for Pdpe02351 larvae.

      (Takeuchi et al., 2009)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Dgatsugari
      Dgatu
      Name Synonyms
      atsugari
      (Takeuchi et al., 2001)
      Secondary FlyBase IDs
        References (2)