FlyBase Allele Report: Dmel\rt[EP571]

General Information

Symbol

Dmel\rt^EP571

Species

D. melanogaster

Name

FlyBase ID

FBal0129099

Feature type

allele

Associated gene

Dmel\rt

Associated Insertion(s)

P{EP}rt^EP571

Carried in Construct

Also Known As

rt⁵⁷¹

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Gene Disruption Project members, 2001-)

Progenitor genotype

Associated Insertion(s)

P{EP}rt^EP571

Cytology

Description

Allele components

Component

Use(s)

Inserted element

P{EP}

misexpression element

Regulatory region(s)

UAS

binary expression system - regulatory region

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

3L:11,587,133..11,587,133 [-]

(Monagas-Valentin et al., 2023, Lyalin et al., 2006, Gene Disruption Project members, 2001-)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of Walker-Warburg syndrome

CEA with rt^KG04772

(Ueyama et al., 2010)

model of muscular dystrophy-dystroglycanopathy

CEA with rt²

(Monagas-Valentin et al., 2023)

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal flight (with rt^KG04772)

(Ueyama et al., 2010)

abnormal locomotor behavior | adult stage (with rt^KG04772)

(Ueyama et al., 2010)

Phenotype Manifest In

adult abdomen

(Lyalin et al., 2006)

adult abdomen (with rt^P)

(Lyalin et al., 2006)

embryonic/larval somatic muscle cell (with rt^KG04772)

(Ueyama et al., 2010)

Detailed Description

Statement

Reference

rt^KG04772/rt^EP571 adults have significantly decreased climbing ability compared to control flies at all ages tested. The mutant flies also have reduced flight ability compared to controls.

Deficient or thin muscles are sometimes seen in the abdominal segments of rt^KG04772/rt^EP571 larvae.

(Ueyama et al., 2010)

rt^EP571 and rt^P/rt^EP571 flies have rotated abdomens.

(Lyalin et al., 2006)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

NOT Enhanced by

Statement

Reference

rt^P/rt^EP571 has adult abdomen phenotype, non-enhanceable by Dp(1;Y)y²sc/+

(Lyalin et al., 2006)

Suppressed by

Statement

Reference

rt^P/rt^EP571 has adult abdomen phenotype, suppressible by tw[+]/tw¹

(Lyalin et al., 2006)

rt^EP571 has adult abdomen phenotype, suppressible by tw[+]/tw¹

(Lyalin et al., 2006)

Additional Comments

Genetic Interactions

Statement

Reference

The rotated abdomen phenotype is suppressed in tw¹/Y; rt^EP571 flies.

The rotated abdomen phenotype of rt^P/rt^EP571 flies is not enhanced by the presence of the Dp(1;Y)y²sc duplication.

(Lyalin et al., 2006)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

rt⁵⁷¹

(Monagas-Valentin et al., 2023, Lyalin et al., 2006)

rt^EP571

(Ueyama et al., 2010)

rt^EP

(Ueyama et al., 2010)

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

Open Close