FlyBase Allele Report: Dmel\ttk[69.UAS]

Expression of ttk^69.Scer\UAS under the control of Scer\GAL4^GMR.PF causes a distorted eye morphology characterized by disorganised facets and a loss of bristles. The cone cell pattern in the ommatidium of 40hr old pupal eye discs is also severely disrupted. The photoreceptor pattern is severely disrupted.

(Bajpe et al., 2008)

When ttk^69.Scer\UAS is driven by Scer\GAL4^Bx-MS1096 the wing blade area is reduced and all sensilla are removed except the ventral mechanosensory bristles. Sensory organ precursors are ablated in the wing disc.

(Badenhorst et al., 2002)

Expression of ttk^69.Scer\UAS under the control of Scer\GAL4^GMR.PF abolishes the second mitotic wave in the eye disc. The proportion of cells behind the furrow in G2 is increased in these discs compared to wild type.

(Baonza et al., 2002)

Expression of ttk^69.Scer\UAS under the control of Scer\GAL4^elav-C155 results in pathfinding and fasciculation defects in the central nervous system (CNS). The longitudinal fascicles are disorganised and the intersegmental nerve is misrouted and often fails to exit the CNS. Organisation of the peripheral nervous system is unaffected. Expression of ttk^69.Scer\UAS under the control of Scer\GAL4^Kr.PM inhibits normal glial development. Longitudinal glia are ablated when ttk^69.Scer\UAS is expressed under the control of Scer\GAL4^sca-537.4. The number of longitudinal glia is reduced when ttk^69.Scer\UAS is expressed under the control of Scer\GAL4^MZ1580. The normal BrdU incorporation in the ventral neuroectoderm is inhibited in embryos expressing ttk^69.Scer\UAS under the control of Scer\GAL4^Kr.PM.

(Badenhorst, 2001)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Scer\GAL4^GMR.PF, ttk^69.UAS has visible phenotype, enhanceable by Usp47^UAS.cBa/Scer\GAL4^GMR.PF

(Bajpe et al., 2008)

NOT Enhanced by

Statement

Reference

Scer\GAL4^GMR.PF, ttk^69.UAS has visible phenotype, non-enhanceable by Usp47^C405A.UAS/Scer\GAL4^GMR.PF

(Bajpe et al., 2008)

Suppressed by

Statement

Reference

Scer\GAL4^GMR.PF, ttk^69.UAS has visible phenotype, suppressible | partially by Ubp64E[+]/Usp47^Δ1

(Bajpe et al., 2008)

NOT suppressed by

Statement

Reference

Scer\GAL4^GMR.PF, ttk^69.UAS has visible phenotype, non-suppressible by Ubp64E[+]/Usp47^Rev

(Bajpe et al., 2008)

Enhancer of

Statement

Reference

ttk^69.UAS/Scer\GAL4^GMR.PF is an enhancer of visible phenotype of Scer\GAL4^GMR.PF, Usp47^UAS.cBa

(Bajpe et al., 2008)

Phenotype Manifest In

Enhanced by

Statement

Reference

Scer\GAL4^GMR.PF, ttk^69.UAS has interommatidial bristle phenotype, enhanceable by Usp47^UAS.cBa/Scer\GAL4^GMR.PF

(Bajpe et al., 2008)

Scer\GAL4^GMR.PF, ttk^69.UAS has eye disc | pupal stage phenotype, enhanceable by Usp47^UAS.cBa/Scer\GAL4^GMR.PF

(Bajpe et al., 2008)

Scer\GAL4^GMR.PF, ttk^69.UAS has ommatidium | pupal stage phenotype, enhanceable by Usp47^UAS.cBa/Scer\GAL4^GMR.PF

(Bajpe et al., 2008)

Scer\GAL4^GMR.PF, ttk^69.UAS has photoreceptor neuron | pupal stage phenotype, enhanceable by Usp47^UAS.cBa/Scer\GAL4^GMR.PF

(Bajpe et al., 2008)

ttk^69.UAS has cone cell | pupal stage phenotype, enhanceable by Usp47^UAS.cBa/Scer\GAL4^GMR.PF

(Bajpe et al., 2008)

Scer\GAL4^GMR.PF, ttk^69.UAS has eye phenotype, enhanceable by Usp47^UAS.cBa/Scer\GAL4^GMR.PF

(Bajpe et al., 2008)

Scer\GAL4^GMR.PF, ttk^69.UAS has ommatidium | adult stage phenotype, enhanceable by Usp47^UAS.cBa/Scer\GAL4^GMR.PF

(Bajpe et al., 2008)

NOT Enhanced by

Statement

Reference

Scer\GAL4^GMR.PF, ttk^69.UAS has eye phenotype, non-enhanceable by Usp47^C405A.UAS/Scer\GAL4^GMR.PF

(Bajpe et al., 2008)

Scer\GAL4^GMR.PF, ttk^69.UAS has ommatidium | adult stage phenotype, non-enhanceable by Usp47^C405A.UAS/Scer\GAL4^GMR.PF

(Bajpe et al., 2008)

Scer\GAL4^GMR.PF, ttk^69.UAS has interommatidial bristle phenotype, non-enhanceable by Usp47^C405A.UAS/Scer\GAL4^GMR.PF

(Bajpe et al., 2008)

Scer\GAL4^GMR.PF, ttk^69.UAS has eye disc | pupal stage phenotype, non-enhanceable by Usp47^C405A.UAS/Scer\GAL4^GMR.PF

(Bajpe et al., 2008)

Scer\GAL4^GMR.PF, ttk^69.UAS has ommatidium | pupal stage phenotype, non-enhanceable by Usp47^C405A.UAS/Scer\GAL4^GMR.PF

(Bajpe et al., 2008)

Scer\GAL4^GMR.PF, ttk^69.UAS has cone cell | pupal stage phenotype, non-enhanceable by Usp47^C405A.UAS/Scer\GAL4^GMR.PF

(Bajpe et al., 2008)

Scer\GAL4^GMR.PF, ttk^69.UAS has photoreceptor neuron | pupal stage phenotype, non-enhanceable by Usp47^C405A.UAS/Scer\GAL4^GMR.PF

(Bajpe et al., 2008)

Suppressed by

Statement

Reference

Scer\GAL4^GMR.PF, ttk^69.UAS has eye phenotype, suppressible | partially by Ubp64E[+]/Usp47^Δ1

(Bajpe et al., 2008)

Scer\GAL4^GMR.PF, ttk^69.UAS has ommatidium | adult stage phenotype, suppressible | partially by Ubp64E[+]/Usp47^Δ1

(Bajpe et al., 2008)

Scer\GAL4^GMR.PF, ttk^69.UAS has interommatidial bristle phenotype, suppressible | partially by Ubp64E[+]/Usp47^Δ1

(Bajpe et al., 2008)

Scer\GAL4^GMR.PF, ttk^69.UAS has eye disc | pupal stage phenotype, suppressible | partially by Ubp64E[+]/Usp47^Δ1

(Bajpe et al., 2008)

Scer\GAL4^GMR.PF, ttk^69.UAS has ommatidium | pupal stage phenotype, suppressible | partially by Ubp64E[+]/Usp47^Δ1

(Bajpe et al., 2008)

Scer\GAL4^GMR.PF, ttk^69.UAS has cone cell | pupal stage phenotype, suppressible | partially by Ubp64E[+]/Usp47^Δ1

(Bajpe et al., 2008)

Scer\GAL4^GMR.PF, ttk^69.UAS has photoreceptor neuron | pupal stage phenotype, suppressible | partially by Ubp64E[+]/Usp47^Δ1

(Bajpe et al., 2008)

Scer\GAL4^GMR.PF, ttk^69.UAS has mitotic cell cycle phenotype, suppressible by stg^UAS.cNa/Scer\GAL4^GMR.PF

(Baonza et al., 2002)

Scer\GAL4^GMR.PF, ttk^69.UAS has eye disc phenotype, suppressible by stg^UAS.cNa/Scer\GAL4^GMR.PF

(Baonza et al., 2002)

NOT suppressed by

Statement

Reference

Scer\GAL4^GMR.PF, ttk^69.UAS has eye phenotype, non-suppressible by Ubp64E[+]/Usp47^Rev

(Bajpe et al., 2008)

Scer\GAL4^GMR.PF, ttk^69.UAS has ommatidium | adult stage phenotype, non-suppressible by Ubp64E[+]/Usp47^Rev

(Bajpe et al., 2008)

Scer\GAL4^GMR.PF, ttk^69.UAS has interommatidial bristle phenotype, non-suppressible by Ubp64E[+]/Usp47^Rev

(Bajpe et al., 2008)

Scer\GAL4^GMR.PF, ttk^69.UAS has eye disc | pupal stage phenotype, non-suppressible by Ubp64E[+]/Usp47^Rev

(Bajpe et al., 2008)

Scer\GAL4^GMR.PF, ttk^69.UAS has ommatidium | pupal stage phenotype, non-suppressible by Ubp64E[+]/Usp47^Rev

(Bajpe et al., 2008)

Scer\GAL4^GMR.PF, ttk^69.UAS has cone cell | pupal stage phenotype, non-suppressible by Ubp64E[+]/Usp47^Rev

(Bajpe et al., 2008)

Scer\GAL4^GMR.PF, ttk^69.UAS has photoreceptor neuron | pupal stage phenotype, non-suppressible by Ubp64E[+]/Usp47^Rev

(Bajpe et al., 2008)

Enhancer of

Statement

Reference

ttk^69.UAS/Scer\GAL4^GMR.PF is an enhancer of eye phenotype of Scer\GAL4^GMR.PF, Usp47^UAS.cBa

(Bajpe et al., 2008)

ttk^69.UAS/Scer\GAL4^GMR.PF is an enhancer of ommatidium | adult stage phenotype of Scer\GAL4^GMR.PF, Usp47^UAS.cBa

(Bajpe et al., 2008)

ttk^69.UAS/Scer\GAL4^GMR.PF is an enhancer of interommatidial bristle phenotype of Scer\GAL4^GMR.PF, Usp47^UAS.cBa

(Bajpe et al., 2008)

ttk^69.UAS/Scer\GAL4^GMR.PF is an enhancer of eye disc | pupal stage phenotype of Scer\GAL4^GMR.PF, Usp47^UAS.cBa

(Bajpe et al., 2008)

ttk^69.UAS/Scer\GAL4^GMR.PF is an enhancer of ommatidium | pupal stage phenotype of Scer\GAL4^GMR.PF, Usp47^UAS.cBa

(Bajpe et al., 2008)

ttk^69.UAS/Scer\GAL4^GMR.PF is an enhancer of photoreceptor neuron | pupal stage phenotype of Scer\GAL4^GMR.PF, Usp47^UAS.cBa

(Bajpe et al., 2008)

ttk^69.UAS/Scer\GAL4^GMR.PF is an enhancer of cone cell | pupal stage phenotype of Scer\GAL4^GMR.PF, Usp47^UAS.cBa

(Bajpe et al., 2008)

Additional Comments

Genetic Interactions

Statement

Reference

One copy of Ubp64E^Δ1 strongly suppresses the adult eye morphology phenotype seen when ttk^69.Scer\UAS is expressed under the control of Scer\GAL4^GMR.PF. The cone cell disruption see in pupal eye discs is also suppressed, as is the disruption to the photoreceptor pattern.

One copy of Ubp64E^Rev is unable to suppress the adult eye morphology phenotype seen when ttk^69.Scer\UAS is expressed under the control of Scer\GAL4^GMR.PF. The cone cell pattern disruption and loss of photoreceptors seen in pupal ommatidia is also unaffected.

Co-expression of ttk^69.Scer\UAS and Ubp64E^Scer\UAS.cBa under the control of Scer\GAL4^GMR.PF causes dramatically defective eye development, more severe than is seen when either transgene is expressed alone. The cone cell disruption seen in the ommatidia of pupal eye discs is also enhanced, as is the disruption to the photoreceptor pattern.

Expression of Ubp64E^{C405A.Scer\UAS} does not enhance the adult eye phenotypes seen when ttk^69.Scer\UAS is expressed under the control of Scer\GAL4^GMR.PF. The cone cell and photoreceptor disruption seen in the ommatidia of pupal eye discs is also unaffected.

(Bajpe et al., 2008)

Coexpression of stg^Scer\UAS.cNa completely rescues the second mitotic wave in eye discs expressing ttk^69.Scer\UAS under the control of Scer\GAL4^GMR.PF.

(Baonza et al., 2002)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

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Notes on Origin

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External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

ttk^69.Scer\UAS

ttk^69.UAS

Name Synonyms

Secondary FlyBase IDs

References (6)

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