FB2024_03 , released June 25, 2024
Allele: Dmel\me31BΔ2
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General Information
Symbol
Dmel\me31BΔ2
Species
D. melanogaster
Name
FlyBase ID
FBal0127208
Feature type
allele
Associated gene
Dmel\me31B
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
Delta2-3 transposase
(Nakamura et al., 2001)
Progenitor genotype
me31Bk06607
(Nakamura et al., 2001)
Cytology
Description

Imprecise excision of the P{lacW} element resulting in a deletion starting from the original insertion point of the element and extending into the me31B coding region.

(Nakamura et al., 2001)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygotes die during the 2nd to 3rd larval instar without any discernible morphological defects. Homozygous egg chambers in female germ-line clones do not complete oogenesis. Most of the egg chambers degenerate during mid-oogenesis, such that the cell membranes of germline cells are collapsed and ring canals and nurse cell nuclei are concentrated to form large aggregates within egg chambers. Nurse cell nuclei in these egg chambers are then fragmented into small pieces. Occasionally, egg chambers which have progressed to stage 10 are seen. In these egg chambers, the oocyte does not grow normally the and the nurse cell nuclei are displaced posteriorly relative to the anterior border of columnar follicle cells (which normally surround the oocyte at stage 10). The egg chambers are morphologically normal until stage 4-5 and the oocyte fails to grow normally from stage 6 onwards, at which stage the egg chambers begin to degenerate.

      (Nakamura et al., 2001)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Statement
      Reference

      Fmr13, me31B[+]/me31BΔ2 has abnormal learning | dominant phenotype, suppressible by Fmr1+t14

      (Sudhakaran et al., 2014)

      Atx2X1, me31B[+]/me31BΔ2 has abnormal learning | dominant phenotype, suppressible by Atx2+t10.4

      (McCann et al., 2011)
      Other
      Statement
      Reference

      Fmr13, me31B[+]/me31BΔ2 has abnormal learning | dominant phenotype

      (Sudhakaran et al., 2014)

      Atx2X1, me31B[+]/me31BΔ2 has abnormal learning | dominant phenotype

      (McCann et al., 2011)
      Phenotype Manifest In
      Suppressed by
      Statement
      Reference

      Atx2X1, me31B[+]/me31BΔ2 has antennal lobe glomerulus DM5 phenotype, suppressible by Atx2+t10.4

      (McCann et al., 2011)

      Atx2X1, me31B[+]/me31BΔ2 has antennal lobe glomerulus V phenotype, suppressible by Atx2+t10.4

      (McCann et al., 2011)
      Other
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Fmr1Δ50M, me31BΔ2 double heterozygotes exhibit a complete block of the long-term habituation (LTH) normally seen when flies are exposed to either ethyl butyrate (EB) or CO[[2]]] for 4 days. LTH appears normal in either heterozygote alone. This loss of EB-evoked LTH is restored by expression of Fmr1+t14. Short term habituation following one hour exposure to EB appears normal.

      (Sudhakaran et al., 2014)

      me31BΔ2, Atx2X1 double heterozygotes exhibit a complete block of the long-term habituation (LTH) seen when flies are exposed to either ethyl butyrate (EB) or CO[[2]]] for 4 days. LTH appears normal in either heterozygote alone. This loss of EB-evoked LTH is restored by expression of Atx2+t10.4. Short term habituation following 1 hour exposure to EB appears normal. LTH-associated structural plasticity is also blocked: although the V and DM5 glomeruli of Atx2X1/+ flies show the expected growth following 4d of CO[[2]] or EB exposure, respectively, both the EB-evoked increase in DM5 volume and the CO[[2]]-induced increase in V are abolished in me31BΔ2/+; Atx2X1/+ double heterozygotes. These defects in structural plasticity are restored by Atx2+t10.4.

      (McCann et al., 2011)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Me31BΔ2
      (McCann et al., 2011)
      me31BΔ2
      (Davidson et al., 2016, Sudhakaran et al., 2014)
      me31BΔ2
      (Pushpalatha et al., 2022)
      Name Synonyms
      Secondary FlyBase IDs
        References (5)