FB2024_03 , released June 25, 2024
Allele: Dmel\Atx2+t10.4
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General Information
Symbol
Dmel\Atx2+t10.4
Species
D. melanogaster
Name
FlyBase ID
FBal0296617
Feature type
allele
Associated gene
Dmel\Atx2
Associated Insertion(s)
Carried in Construct
PBac{Atx2+t10.4}
Key Links
Transgenic product class
genomic_DNA
(McCann et al., 2011)
wild_type
(McCann et al., 2011)
Mutagen
Nature of the Allele
Transgenic product class
genomic_DNA
(McCann et al., 2011)
wild_type
(McCann et al., 2011)
Mutagen
in vitro construct
(McCann et al., 2011)
Progenitor genotype
Carried in construct
PBac{Atx2+t10.4}
Cytology
Description

A 10.4kb genomic construct (genomic coordinates 11232657-112430820) containing Atx2 including the upstream and downstream regions.

(McCann et al., 2011)
Allele components
Component
Use(s)
Regulatory region(s)
Atx2
Encoded product / tool
Atx2
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  spinocerebellar ataxia type 2
      modeled by Atx2X1
      (Bakthavachalu et al., 2018)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Adult Atx2X1/Atx206490 transheterozygotes bearing Atx2+t10.4 do not exhibit long-term olfactory habituation defects, as compared to controls.

      (Bakthavachalu et al., 2018)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      Atx2+t10.4 is a suppressor of abnormal learning | dominant phenotype of Atx2X1/Atx2[+], Fmr13

      (Sudhakaran et al., 2014)

      Atx2+t10.4 is a suppressor of abnormal learning | dominant phenotype of AGO1k08121/AGO1[+], Atx2X1

      (McCann et al., 2011)

      Atx2+t10.4 is a suppressor of abnormal learning | dominant phenotype of Atx2X1, me31B[+]/me31BΔ2

      (McCann et al., 2011)
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      Atx2+t10.4 is a suppressor of antennal lobe glomerulus DM5 phenotype of AGO1k08121/AGO1[+], Atx2X1

      (McCann et al., 2011)

      Atx2+t10.4 is a suppressor of antennal lobe glomerulus V phenotype of AGO1k08121/AGO1[+], Atx2X1

      (McCann et al., 2011)

      Atx2+t10.4 is a suppressor of antennal lobe glomerulus DM5 phenotype of Atx2X1, me31B[+]/me31BΔ2

      (McCann et al., 2011)

      Atx2+t10.4 is a suppressor of antennal lobe glomerulus V phenotype of Atx2X1, me31B[+]/me31BΔ2

      (McCann et al., 2011)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Fmr13, Atx2X1 double heterozygotes exhibit a complete block of the long-term habituation (LTH) normally seen when flies are exposed to either ethyl butyrate (EB) or CO[[2]]] for 4 days. LTH appears normal in either heterozygote alone. This loss of EB-evoked LTH is restored by expression of either Atx2+t10.4 or Fmr1+t14. Short term habituation following one hour exposure to EB appears normal.

      (Sudhakaran et al., 2014)

      AGO1k08121, Atx2X1 double heterozygotes exhibit a complete block of the long-term habituation (LTH) seen when flies are exposed to either ethyl butyrate (EB) or CO[[2]]] for 4 days. LTH appears normal in either heterozygote alone. This loss of EB-evoked LTH is restored by expression of Atx2+t10.4. Short term habituation following one hour exposure to EB appears normal. LTH-associated structural plasticity is also blocked: although the V and DM5 glomeruli of Atx2X1/+ flies show the expected growth following 4d of CO[[2]] or EB exposure, respectively, both the EB-evoked increase in DM5 volume and the CO[[2]]-induced increase in V are abolished in AGO1k08121/+; Atx2X1/+ double heterozygotes. These defects in structural plasticity are restored by Atx2+t10.4.

      me31BΔ2, Atx2X1 double heterozygotes exhibit a complete block of the long-term habituation (LTH) seen when flies are exposed to either ethyl butyrate (EB) or CO[[2]]] for 4 days. LTH appears normal in either heterozygote alone. This loss of EB-evoked LTH is restored by expression of Atx2+t10.4. Short term habituation following 1 hour exposure to EB appears normal. LTH-associated structural plasticity is also blocked: although the V and DM5 glomeruli of Atx2X1/+ flies show the expected growth following 4d of CO[[2]] or EB exposure, respectively, both the EB-evoked increase in DM5 volume and the CO[[2]]-induced increase in V are abolished in me31BΔ2/+; Atx2X1/+ double heterozygotes. These defects in structural plasticity are restored by Atx2+t10.4.

      (McCann et al., 2011)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Atx2+t10.4
      Name Synonyms
      Secondary FlyBase IDs
        References (3)