FlyBase Allele Report: Dmel\Fmr1[+t14]

General Information

Symbol

Dmel\Fmr1^+t14

Species

D. melanogaster

Name

FlyBase ID

FBal0137502

Feature type

allele

Associated gene

Dmel\Fmr1

Associated Insertion(s)

Carried in Construct

P{Fmr1.14}

Key Links

Genomic Maps

JBrowse

Transgenic product class

genomic_DNA

(Dockendorff et al., 2002)

wild_type

(Dockendorff et al., 2002)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

genomic_DNA

(Dockendorff et al., 2002)

wild_type

(Dockendorff et al., 2002)

Mutagen

in vitro construct

(Dockendorff et al., 2002)

Progenitor genotype

Carried in construct

P{Fmr1.14}

Cytology

Description

14kb genomic BamHI-StuI fragment that encompasses the entire Fmr1 transcription unit.

(Dockendorff et al., 2002)

Allele components

Component

Use(s)

Regulatory region(s)

Fmr1

Encoded product / tool

Fmr1

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

rescue_region

3R:10,099,998..10,114,015 [-]

Linked to:

BamHI-StuI restriction fragment

Comment:

Position of restriction fragment on reference sequence inferred by FlyBase curator.

(Lee et al., 2003, Dockendorff et al., 2002)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

wild-type

(Dockendorff et al., 2002)

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Fmr1^+t14 is a suppressor of abnormal learning | dominant phenotype of Atx2^X1/Atx2[+], Fmr1³

(Sudhakaran et al., 2014)

Fmr1^+t14 is a suppressor of abnormal learning | dominant phenotype of Fmr1³, me31B[+]/me31B^Δ2

(Sudhakaran et al., 2014)

Fmr1^+t14 is a suppressor of abnormal learning | dominant phenotype of AGO1^k08121/AGO1[+], Fmr1³

(Sudhakaran et al., 2014)

Fmr1^+t14 is a suppressor of abnormal size | somatic clone | adult stage phenotype of Fmr1^Δ113M, rin²

(Baumgartner et al., 2013)

Fmr1^+t14 is a suppressor of abnormal courtship behavior phenotype of Fmr1³, Psn^B3/Psn[+]

(McBride et al., 2010)

Phenotype Manifest In

Enhancer of

Statement

Reference

Fmr1^+t14 is an enhancer | maternal effect of egg chorion | maternal effect phenotype of Ecol\lacZ^{Hsp83.orb.8E2Hd}, orb^F343

(Costa et al., 2005)

Suppressor of

Statement

Reference

Fmr1^+t14 is a suppressor of ommatidium | increased number | somatic clone phenotype of Fmr1^Δ113M, rin²

(Baumgartner et al., 2013)

NOT Suppressor of

Statement

Reference

Fmr1^+t14 is a non-suppressor of type I bouton phenotype of Adar^5G1

(Bhogal et al., 2011)

Fmr1^+t14 is a non-suppressor of synapse phenotype of Adar^5G1

(Bhogal et al., 2011)

Fmr1^+t14 is a non-suppressor of neuromuscular junction phenotype of Adar^5G1

(Bhogal et al., 2011)

Additional Comments

Genetic Interactions

Statement

Reference

Fmr1^Δ50M, me31B^Δ2 double heterozygotes exhibit a complete block of the long-term habituation (LTH) normally seen when flies are exposed to either ethyl butyrate (EB) or CO[[2]]] for 4 days. LTH appears normal in either heterozygote alone. This loss of EB-evoked LTH is restored by expression of Fmr1^+t14. Short term habituation following one hour exposure to EB appears normal.

Fmr1^Δ50M, AGO1^k08121 double heterozygotes exhibit a complete block of the long-term habituation (LTH) normally seen when flies are exposed to either ethyl butyrate (EB) or CO[[2]]] for 4 days. LTH appears normal in either heterozygote alone. This loss of EB-evoked LTH is restored by expression of Fmr1^+t14. Short term habituation following one hour exposure to EB appears normal.

Fmr1³, Atx2^X1 double heterozygotes exhibit a complete block of the long-term habituation (LTH) normally seen when flies are exposed to either ethyl butyrate (EB) or CO[[2]]] for 4 days. LTH appears normal in either heterozygote alone. This loss of EB-evoked LTH is restored by expression of either Atx2^+t10.4 or Fmr1^+t14. Short term habituation following one hour exposure to EB appears normal.

(Sudhakaran et al., 2014)

rin² Fmr1^Δ113M double mutant eyes, generated by eyFLP/FRT-mediated mitotic recombination, show an increase in ommatidial number under normal food conditions. This phenotype is rescued to a rin² like phenotype by inclusion of Fmr1^+t14.

(Baumgartner et al., 2013)

The presence of four copies of Fmr1^+t14 does not affect the Adar^5G1 mutant phenotype with respect to type 1s and type 1b synaptic boutons, primary branch length and the number of synaptic branches.

A Adar^5G1 heterozygous background in flies expressing four copies of Fmr1^+t14 does neither suppress nor enhance the Fmr1^+t14 phenotype.

(Bhogal et al., 2011)

The courtship behavior of 5-day-old Fmr1³/+;Psn^B3/+ double heterozygous males is severely impaired compared to either of the single heterozygotes that display normal courtship. This defect in naive courtship behavior can be rescued by combination with Fmr1^+t14 allele.

(McBride et al., 2010)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescues

Fmr1^+t14 rescues Fmr1³

(Sudhakaran et al., 2014)

Fmr1^+t14 rescues Fmr1³/Fmr1[+]

(Kanellopoulos et al., 2012)

Fmr1^+t14 rescues Fmr1^Δ50M

(Gatto and Broadie, 2011)

Fmr1^+t14 rescues Fmr1^Δ83M/Fmr1³

(Tauber et al., 2011)

Fmr1^+t14 rescues Fmr1³

(Banerjee et al., 2010)

Fmr1^+t14 rescues Fmr1³

(Choi et al., 2010)

Fmr1^+t14 rescues Fmr1³

(Epstein et al., 2009)

Fmr1^+t14 rescues Fmr1^Δ50M/Fmr1³

(Epstein et al., 2009)

Fmr1^+t14 rescues Fmr1^Δ50M

(Epstein et al., 2009)

Fmr1^+t14 rescues Fmr1³

(Bolduc et al., 2008)

Fmr1^+t14 rescues Fmr1³/Fmr1^B55

(Bolduc et al., 2008)

Fmr1^+t14 rescues Fmr1^B55

(Bolduc et al., 2008)

Fmr1^+t14 rescues Fmr1³

(Deshpande et al., 2006)

Fmr1^+t14 rescues Fmr1³

(Costa et al., 2005)

Fmr1^+t14 rescues Fmr1³

(McBride et al., 2005)

Fmr1^+t14 rescues Fmr1^Δ83M/Fmr1³

(Michel et al., 2004)

Fmr1^+t14 rescues Fmr1³/Fmr1^Δ113M

(Michel et al., 2004)

Fmr1^+t14 rescues Fmr1^4.L/Fmr1³

(Xu et al., 2004)

Fmr1^+t14 rescues Fmr1^4.L

(Lee et al., 2003)

Fmr1^+t14 rescues Fmr1³

(Dockendorff et al., 2002)

Comments

Expression of Fmr1^+t14 rescues the long term habituation (LTH) defects seen in Fmr1³ mutant flies following exposure to either ethyl butyrate (EB) or CO[[2]]] for 4 days.

(Sudhakaran et al., 2014)

Expression of Fmr1^+t14 rescues the learning and memory phenotype of Fmr1³ mutants.

(Kanellopoulos et al., 2012)

Expression of Fmr1^+t14 strongly diminishes PDF-TRI neuron retention in Fmr1^Δ50M mutants.

(Gatto and Broadie, 2011)

Fmr1^+t14 (but not Fmr1^FS) rescues locomotor defects and excessive grooming behavior at all ages (day 5, 15, 25, 35) in Fmr1³/Fmr1^Δ83M flies; courtship behavior defects at day 15 are also rescued by Fmr1^+t14 but not Fmr1^FS.

(Tauber et al., 2011)

Fmr1^+t14 rescues the midline crossing phenotype of mushroom body β-lobe axons that is seen in Fmr1³ adults.

Fmr1^+t14 rescues the increased number of boutons at the neuromuscular junction that is seen in homozygous Fmr1³ larvae.

Fmr1^+t14 almost completely rescues the loss of rhythmic locomotion activity which is seen in Fmr1³ flies under constant darkness conditions.

Fmr1^+t14 rescues the reduction in naive courtship activity seen in Fmr1³ males and also rescues the defects in immediate recall and short-term memory after training, so that the rescued males show a reduction in courtship index at 0-2 and 60 minutes after training when placed with a receptive female.

(Banerjee et al., 2010)

The presence of Fmr1^+t14 rescues the long-term memory defect associated with Fmr1³ or Fmr1^B155 homozygotes and Fmr1³/Fmr1^B155 transheterozygotes.

(Bolduc et al., 2008)

Fmr1^+t14 rescues oogenesis phenotypes seen in Fmr1³ homozygotes.

(Costa et al., 2005)

The defective immediate recall as well and short-term memory characteristic for Fmr1³ mutant males is restored by combination with a single copy of the Fmr1^+t14 transgene.

(McBride et al., 2005)

The presence of a single copy of Fmr1^+t14 to Fmr1³/Fmr1^Δ83M or Fmr1³/Fmr1^Δ113M transheterozygotes greatly reduces the penetrance and expressivity of the β-lobe midline-crossing phenotype.

(Michel et al., 2004)

Fmr1^+t14 rescues the crawling pattern defects of Fmr1³/Fmr1^4.L wandering larvae.

(Xu et al., 2004)

Rescues the dendritic defects seen in Fmr1^4.L.

(Lee et al., 2003)

Rescues rhythmicity and courtship defects of Fmr1³.

(Dockendorff et al., 2002)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Fmr1^+t14

Name Synonyms

Secondary FlyBase IDs

References (27)

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