FB2024_03 , released June 25, 2024
Allele: Dmel\Cdk1UAS.Tag:MYC
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General Information
Symbol
Dmel\Cdk1UAS.Tag:MYC
Species
D. melanogaster
Name
FlyBase ID
FBal0118304
Feature type
allele
Associated gene
Dmel\Cdk1
Associated Insertion(s)
Carried in Construct
P{UAS-Cdk1-myc}
Also Known As
UAS-Cdk1-myc, UAS-Cdk1
Key Links
Transgenic product class
wild_type
(Meyer et al., 2000)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Meyer et al., 2000)
Mutagen
in vitro construct
(Leismann et al., 2000)
Progenitor genotype
Carried in construct
P{UAS-Cdk1-myc}
Cytology
Description

UASt sequences drive expression of Cdk1 tagged with six epitope copies of the Tag:MYC tag at the C terminus.

(Meyer et al., 2000)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Cdk1
Tagged with
Tag:MYC
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Cdk1Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4en-e16E does not affect the size of the adult wing posterior compartment, as compared to controls.

      (Ibar and Glavic, 2017)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The wing posterior compartment size reduction seen in flies expressing p115KK100066 under the control of Scer\GAL4en-e16E is suppressed when Cdk1Scer\UAS.T:Hsap\MYC is co-expressed.

      Co-expression of Cdk1Scer\UAS.T:Hsap\MYC suppresses the increased proportion of cells in S phase or mitosis in the posterior compartment of third instar wing discs expressing p115KK100066 under the control of Scer\GAL4hh.PU, but fails to suppress the increase cell death in these wing discs; no significant changes in cell size or DNA content are seen in these specimens as compared to controls.

      (Ibar and Glavic, 2017)

      Overexpression of cdc2Scer\UAS.T:Hsap\MYC partially suppresses the curly wing phenotype in Scer\GAL4Ser.PGF>Sin3AdsRNA.Scer\UAS.WIZ flies.

      (Swaminathan and Pile, 2010)

      The wing impairment resulting from the ectopic expression of Scer\GAL4MD-638-driven Axud1Scer\UAS.cGa is suppressed by the co-expression of cdc2Scer\UAS.T:Hsap\MYC.

      (Glavic et al., 2009)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Cdk1Scer\UAS.T:Hsap\MYC
      Cdk1UAS.Tag:MYC
      cdc2Scer\UAS.T:Hsap\MYC
      Name Synonyms
      Secondary FlyBase IDs
        References (12)