FlyBase Allele Report: Dmel\Su(H)[UAS.cNa]

General Information

Symbol

Dmel\Su(H)^UAS.cNa

Species

D. melanogaster

Name

Saccharomyces cerevisiae UAS construct a of Nagel

FlyBase ID

FBal0117639

Feature type

allele

Associated gene

Dmel\Su(H)

Associated Insertion(s)

Carried in Construct

P{UAS-Su(H).N}

Also Known As

UAS-Su(H)

Key Links

Transgenic product class

cDNA

(Nagel et al., 2000)

wild_type

(Nagel et al., 2000)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

cDNA

(Nagel et al., 2000)

wild_type

(Nagel et al., 2000)

Mutagen

in vitro construct

(Nagel et al., 2000)

Progenitor genotype

Carried in construct

P{UAS-Su(H).N}

Cytology

Description

UASt sequences drive expression of the Su(H) cDNA.

(Nagel et al., 2000)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

Su(H)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

hyperplasia | adult stage, with Scer\GAL4^Eq

(Nagel et al., 2021)

increased occurrence of cell division | larval stage, with Scer\GAL4^ap-md544

(Nagel et al., 2001)

neoplasia | adult stage, with Scer\GAL4^GMR.PU

(Nagel et al., 2021)

neoplasia | adult stage, with Scer\GAL4^ptc-559.1

(Nagel et al., 2001)

visible, with Scer\GAL4^bi-md653

(Nagel et al., 2005)

visible | adult stage, with Scer\GAL4^GMR.PU

(Nagel et al., 2021)

Phenotype Manifest In

eye, with Scer\GAL4^GMR.PU

(Nagel et al., 2021)

mesothoracic tergum, with Scer\GAL4^Eq

(Nagel et al., 2021)

wing, with Scer\GAL4^bi-md653

(Nagel et al., 2005)

wing, with Scer\GAL4^ptc-559.1

(Nagel et al., 2001)

wing disc, with Scer\GAL4^ap-md544

(Nagel et al., 2001)

wing disc, with Scer\GAL4^Bx-MS1096

(Nagel et al., 2001)

wing vein, with Scer\GAL4^bi-md653

(Nagel et al., 2005)

wing vein, with Scer\GAL4^en-e16E

(Nagel et al., 2001)

Detailed Description

Statement

Reference

The expression of Su(H)^UAS.cNa under the control of Scer\GAL4^GMR.PU induces overgrowths in the eye. Expression under the control of Scer\GAL4^Eq induces an increase in the size of the notum.

(Nagel et al., 2021)

Expression of Su(H)^Scer\UAS.cNa in the wing under the control of Scer\GAL4^bi-md653 results in a loss of veins and balloon-like overgrowth. After eclosion, wings do not inflate.

(Nagel et al., 2005)

When Su(H)^Scer\UAS.cNa is driven by Scer\GAL4^ptc-559.1, an outgrowth in the wing blade is seen. When Scer\GAL4^en-e16E is driven by Scer\GAL4^en-e16E, a loss of wing vein is seen. Su(H)^Scer\UAS.cNa driven by Scer\GAL4^ap-md544 causes overproliferation in the wing disc.

(Nagel et al., 2001)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Scer\GAL4^GMR.PU, Su(H)^UAS.cNa has visible | adult stage phenotype, enhanceable by Mnr^EP555, Scer\GAL4^GMR.PU

(Nagel et al., 2021)

Scer\GAL4^GMR.PU, Su(H)^UAS.cNa has neoplasia | adult stage phenotype, enhanceable by Mnr^EP555, Scer\GAL4^GMR.PU

(Nagel et al., 2021)

Suppressed by

Statement

Reference

Scer\GAL4^Eq, Su(H)^UAS.cNa has hyperplasia | adult stage phenotype, suppressible by Mnr^GD9327, Scer\GAL4^Eq

(Nagel et al., 2021)

Other

Statement

Reference

H^UAS.cMa, Scer\GAL4^bi-md653, Su(H)^UAS.cNa has lethal phenotype

(Nagel et al., 2005)

H^{ΔC.1062-1076.UAS}, Scer\GAL4^bi-md653, Su(H)^UAS.cNa has lethal phenotype

(Nagel et al., 2005)

H^ΔG.UAS, Scer\GAL4^bi-md653, Su(H)^UAS.cNa has lethal phenotype

(Nagel et al., 2005)

H^ΔGC.UAS, Scer\GAL4^bi-md653, Su(H)^UAS.cNa has viable phenotype

(Nagel et al., 2005)

Scer\GAL4^sca-537.4, Su(H)^UAS.cNa, numb^UAS.cWa has visible phenotype

(Nagel et al., 2000)

Phenotype Manifest In

Enhanced by

Statement

Reference

Scer\GAL4^GMR.PU, Su(H)^UAS.cNa has eye phenotype, enhanceable by Mnr^EP555, Scer\GAL4^GMR.PU

(Nagel et al., 2021)

Suppressed by

Statement

Reference

Scer\GAL4^Eq, Su(H)^UAS.cNa has mesothoracic tergum phenotype, suppressible by Mnr^GD9327, Scer\GAL4^Eq

(Nagel et al., 2021)

Enhancer of

Statement

Reference

Su(H)^UAS.cNa, Scer\GAL4^bi-md653 is an enhancer of wing margin bristle phenotype of H^ΔGC.UAS, Scer\GAL4^bi-md653

(Nagel et al., 2005)

Su(H)^UAS.cNa, Scer\GAL4^bi-md653 is an enhancer of wing vein phenotype of H^ΔGC.UAS, Scer\GAL4^bi-md653

(Nagel et al., 2005)

Suppressor of

Statement

Reference

Scer\GAL4^dpp.blk1/Su(H)^UAS.cNa is a suppressor | partially of eye phenotype of eyg¹/eyg^M3-12

(Chao et al., 2004)

Other

Statement

Reference

H^UAS.cMa, Scer\GAL4^bi-md653, Su(H)^UAS.cNa has imaginal disc phenotype

(Nagel et al., 2005)

H^{ΔC.1062-1076.UAS}, Scer\GAL4^bi-md653, Su(H)^UAS.cNa has imaginal disc phenotype

(Nagel et al., 2005)

H^ΔG.UAS, Scer\GAL4^bi-md653, Su(H)^UAS.cNa has imaginal disc phenotype

(Nagel et al., 2005)

Scer\GAL4^sca-537.4, Su(H)^UAS.cNa, numb^UAS.cWa has macrochaeta phenotype

(Nagel et al., 2000)

Scer\GAL4^sca-537.4, Su(H)^UAS.cNa, numb^UAS.cWa has trichogen cell phenotype

(Nagel et al., 2000)

Scer\GAL4^sca-537.4, Su(H)^UAS.cNa, numb^UAS.cWa has tormogen cell | ectopic phenotype

(Nagel et al., 2000)

Additional Comments

Genetic Interactions

Statement

Reference

Su(H)^Scer\UAS.cNa; Scer\GAL4^dpp.blk1. partially restores eye development in eyg¹/eyg^M3-12 flies.

(Chao et al., 2004)

Expression of Su(H)^Scer\UAS.cNa under the control of Scer\GAL4^sca-537.4 generates flies with a reproducible transformation of all trichogens into tormogens. However the internal cells are normal, having one neuron and one sheath cell per overlying double socket. Co-expression of numb^Scer\UAS.cWa with Su(H)^Scer\UAS.cNa driven by Scer\GAL4^sca-537.4 results in flies that are partially bald.

(Nagel et al., 2000)

Expression of Su(H)^Scer\UAS.cNa under the control of Scer\GAL4^sca-537.4 with a reproducible transformation of all trichogens into tormogens. However the internal cells are normal, having one neuron and one sheath cell per overlying double socket. Co-expression of numb^Scer\UAS.cWa with Su(H)^Scer\UAS.cNa driven by Scer\GAL4^sca-537.4 results in flies that are partially bald.

(Nagel et al., 2000)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Su(H)^Scer\UAS.cNa

Su(H)^UAS.cNa

Name Synonyms

Saccharomyces cerevisiae UAS construct a of Nagel

(Nagel et al., 2000)

Secondary FlyBase IDs

References (5)

Report Sections

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