FlyBase Allele Report: Dmel\Cdk2[2]

General Information

Symbol

Dmel\Cdk2²

Species

D. melanogaster

Name

FlyBase ID

FBal0117572

Feature type

allele

Associated gene

Dmel\Cdk2

Associated Insertion(s)

Carried in Construct

Also Known As

cdc2c²

Key Links

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Lane et al., 2000)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

decreased body size | larval stage (with Cdk2³)

(Lane et al., 2000)

lethal | recessive

(Lane et al., 2000)

Phenotype Manifest In

Detailed Description

Statement

Reference

Hemizygous embryos appear to have wild-type morphology. They incorporate BrdU with normal efficiency and in normal patterns throughout embryogenesis. Hatching of larvae occurs at the same rate as that of control embryos. cdc2c²/cdc2c³ larvae survive for at least 4 days after egg deposition, but their size fails to increase significantly after 1.5 days (in contrast to wild-type larvae).

(Lane et al., 2000)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhancer of

Statement

Reference

Cdk2²/cdc2c[+] is a non-enhancer of visible phenotype of mi¹/mi^ΔEY22

(Szuplewski et al., 2009)

Suppressor of

Statement

Reference

Cdk2²/cdc2c[+] is a suppressor of visible phenotype of CycE^I.hs.2sev

(Lane et al., 2000)

NOT Suppressor of

Statement

Reference

Cdk2²/cdc2c[+] is a non-suppressor of visible phenotype of mi¹/mi^ΔEY22

(Szuplewski et al., 2009)

Other

Statement

Reference

Cdk2²/cdc2c[+], CycD² has lethal phenotype

(Emmerich et al., 2004)

Cdk2², CycD² has lethal | dominant phenotype

(Emmerich et al., 2004)

Cdk2², CycD¹ has lethal | dominant phenotype

(Emmerich et al., 2004)

Cdk2²/cdc2c[+], CycD¹ has lethal phenotype

(Emmerich et al., 2004)

Phenotype Manifest In

NOT Enhancer of

Statement

Reference

Cdk2²/cdc2c[+] is a non-enhancer of macrochaeta & thorax phenotype of mi¹/mi^ΔEY22

(Szuplewski et al., 2009)

Suppressor of

Statement

Reference

Cdk2²/cdc2c[+] is a suppressor of eye phenotype of CycE^I.hs.2sev

(Lane et al., 2000)

Cdk2²/cdc2c[+] is a suppressor of ommatidium phenotype of CycE^I.hs.2sev

(Lane et al., 2000)

NOT Suppressor of

Statement

Reference

Cdk2²/cdc2c[+] is a non-suppressor of macrochaeta & thorax phenotype of mi¹/mi^ΔEY22

(Szuplewski et al., 2009)

Additional Comments

Genetic Interactions

Statement

Reference

Heterozygosity for either cdc2c² or cdc2c³ has no effect on the small bristle phenotype of mi¹/mi^ΔEY22 flies.

(Szuplewski et al., 2009)

Adult viability of CycD¹/Y ; cdc2c²/+ males is only 6% of expected value. Adult viability of CycD²/Y ; cdc2c²/+ males is only 2% of expected value.

(Emmerich et al., 2004)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Cdk2²/Cdk2¹ is rescued by Cdk2^hs.PS

(Lane et al., 2000)

Cdk2²/Cdk2¹ is rescued by Cdk2^AF.hs

(Lane et al., 2000)

Cdk2³/Cdk2² is rescued by Cdk2^hs.PS

(Lane et al., 2000)

Cdk2³/Cdk2² is rescued by Cdk2^AF.hs

(Lane et al., 2000)

Cdk2²/Df(3R)H⁸¹ is rescued by Cdk2^+t10

(Lane et al., 2000)

Comments

cdc2c²/cdc2c³ or cdc2c¹/cdc2c² females that have been rescued by periodic expression of cdc2c^hs.PS readily lay eggs as long as they are subjected to periodic heat shocks (to induce expression of cdc2c^hs.PS). However, after termination of periodic heat shocks, egg deposition decreases rapidly and stops completely within 2-3 days. This arrest of egg deposition can be readily reversed within 7 days after resumption of periodic heat shocks. Eggs collected from females 1 day after termination of periodic heat shocks often show abnormal spatial distribution of nuclei and the chromatin often appears abnormal. A significant fraction of embryos contain very few nuclei. A significant fraction of embryos contain very few nuclei. About two-thirds of eggs with less than 5 nuclei are not fertilised. Periodic expression of cdc2c^hs.PS (using heat shock) in cdc2c²/cdc2c³ animals allows them to develop into morphologically normal and fertile adults. Some animals are still observed to develop into adults even if the onset of periodic expression of cdc2c^hs.PS is delayed until 116 hours after egg deposition.

(Lane et al., 2000)

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

6632

w^*; Cdk2²/TM3, Sb¹ P{35UZ}2

Notes on Origin

Discoverer

Selected as: a dominant modifier of the CycE^I.hs.2sev rough eye phenotype.

(Lane et al., 2000)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Cdk2²

(Hur et al., 2020, Emmerich et al., 2004, Lane et al., 2000)

cdc2c²

(Wang and Baker, 2015, Swaminathan et al., 2010, Szuplewski et al., 2009)

Name Synonyms

Secondary FlyBase IDs

References (6)

Report Sections

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