FlyBase Allele Report: Dmel\sns[ZF1.4]

General Information

Symbol

Dmel\sns^ZF1.4

Species

D. melanogaster

Name

FlyBase ID

FBal0117346

Feature type

allele

Associated gene

Dmel\sns

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Bour et al., 2000)

Progenitor genotype

Cytology

Description

Amino acid replacement: ?356term.

(Bour et al., 2000)

Nucleotide substitution: C?T.

(Bour et al., 2000)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

2R:8,824,004..8,824,004 [+]

Nucleotide change:

C8824004T

Reported nucleotide change:

C?T

Amino acid change:

R354term | sns-PA; R354term | sns-PB; R354term | sns-PC

Reported amino acid change:

?356term

(Bour et al., 2000)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

The structure of the nephrocyte diaphragms of the garland cell nephrocytes are abnormal (when analysed by TEM) in larvae expressing sns^{mIg4.Scer\UAS} under the control of Scer\GAL4^sns.PK in a sns^ZF1.4/sns^ZF1.4 background.

The structure of the nephrocyte diaphragms of the garland cell nephrocytes are abnormal (when analysed by TEM) in larvae expressing sns^{mIg6.Scer\UAS} under the control of Scer\GAL4^sns.PK in a sns^ZF1.4/sns^ZF1.4 background.

(Zhuang et al., 2009)

The extent of myoblast fusion in sns^ZF1.4 embryos is significantly reduced compared to wild type.

(Menon et al., 2005)

The palisade of circular visceral muscle founder cells is distinctly separated from the adjacent population of fusion-competent cells in stage 13 mutant embryos, in contrast to wild type where they are closely apposed.

(San Martin et al., 2001)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Suppressed by

Statement

Reference

sns^ZF1.4 has embryonic myoblast phenotype, suppressible by hbs::sns^{UAS.HESTC.Tag:HA}/Scer\GAL4^sns.PK

(Shelton et al., 2009)

sns^ZF1.4 has embryonic myoblast phenotype, suppressible by hbs::sns^{UAS.SETHC.Tag:HA}/Scer\GAL4^sns.PK

(Shelton et al., 2009)

sns^ZF1.4 has embryonic myoblast phenotype, suppressible by hbs::sns^{UAS.SEHTC.Tag:HA}/Scer\GAL4^sns.PK

(Shelton et al., 2009)

sns^ZF1.4 has embryonic myoblast phenotype, suppressible by Scer\GAL4^sns.PK/hbs^UAS.Tag:HA

(Shelton et al., 2009)

NOT suppressed by

Statement

Reference

sns^XB3/sns^ZF1.4 has embryonic myoblast phenotype, non-suppressible by Scer\GAL4^how-24B/sns^{UAS.Tag:GPI(Fas1)}

(Galletta et al., 2004)

Additional Comments

Genetic Interactions

Statement

Reference

Scer\GAL4^sns.PK-mediated expression of hbs::sns^{Scer\UAS.HESTC.T:Ivir\HA1} rescues the sns^ZF1.4 myoblast fusion phenotype.

Scer\GAL4^sns.PK-mediated expression of hbs::sns^{Scer\UAS.SETHC.T:Ivir\HA1}, hbs::sns^{Scer\UAS.SEHTC.T:Ivir\HA1} or hbs^{Scer\UAS.cSa.T:Ivir\HA1} partially rescues the sns^ZF1.4 myoblast fusion phenotype.

(Shelton et al., 2009)

Expression of Fas1::sns^GPI.Scer\UAS under the control of Scer\GAL4^how-24B fails to rescue the mutant phenotype of sns^ZF1.4/sns^XB3 embryos. Fusion competent myoblasts do not appear to migrate towards the founder cells in these embryos.

(Galletta et al., 2004)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

sns^43-49

(Bour et al., 2000)

Rescued by

sns^ZF1.4 is rescued by sns^UAS.Tag:HA

(Shelton et al., 2009)

sns^ZF1.4 is rescued by Scer\GAL4^sns.PK/sns^UAS.Tag:HA