FB2024_03 , released June 25, 2024
Allele: Dmel\snsUAS.cGa
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General Information
Symbol
Dmel\snsUAS.cGa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Galletta
FlyBase ID
FBal0175466
Feature type
allele
Associated gene
Dmel\sns
Associated Insertion(s)
Carried in Construct
P{UAS-sns.G}
Also Known As
UAS-sns
Key Links
Transgenic product class
wild_type
(Galletta et al., 2004)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Galletta et al., 2004)
Mutagen
in vitro construct
(Galletta et al., 2004)
Progenitor genotype
Carried in construct
P{UAS-sns.G}
Cytology
Description

UASt regulatory sequences drive expression of full length sns.

(Galletta et al., 2004)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
sns
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Clonal expression of a single copy of snsScer\UAS.cGa in an isolated cell (under the control of Scer\GAL4GMR.PF) does not affect cell-cell contact.

      Expression of two copies of snsScer\UAS.cGa in an isolated cell (under the control of Scer\GAL4GMR.PF) results in 52% of target cells becoming fully separated from ommatidia. Low levels of sns (i.e. one copy of snsScer\UAS.cGa) does not significantly alter the sorting behaviour of the target cells, moderate levels lead to partial segregation, and high levels lead to fully segregated inter-ommatidial cells.

      (Bao et al., 2010)

      Expression of snsScer\UAS.cGa under the control of Scer\GAL4447.2 results in defects in embryonic garland cells; foot process morphology is abnormal and there is a marked thickening of diaphragm filaments.

      (Weavers et al., 2009)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhanced by
      Enhancer of
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Clonal expression of both hbsScer\UAS.cDa and snsScer\UAS.cGa within a single inter-ommatidial cell leads to a newly emergent, striking phenotype: 41% of hbs/sns-targeted inter-ommatidial cells are fully separated from ommatidia with neighboring inter-ommatidial cells intercalated around all sides of the cell. Surrounding inter-ommatidial cells maintain small interfaces with each other but larger interfaces with the hbs/sns-targeted cell.

      (Bao et al., 2010)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      Scer\GAL4how-24B/snsUAS.cGa rescues snsXB3/snsZF1.4

      (Galletta et al., 2004)
      Comments

      Expression of snsScer\UAS.cGa under the control of Scer\GAL4how-24B rescues myoblast fusion in snsZF1.4/snsXB3 embryos and these animals develop into viable adults.

      (Galletta et al., 2004)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      snsScer\UAS.cGa
      snsUAS.cGa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Galletta
      (Galletta et al., 2004)
      Secondary FlyBase IDs
        References (5)