FB2024_03 , released June 25, 2024
Allele: Dmel\Ptp69DD1689
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General Information
Symbol
Dmel\Ptp69DD1689
Species
D. melanogaster
Name
FlyBase ID
FBal0104731
Feature type
allele
Associated gene
Dmel\Ptp69D
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Newsome et al., 2000)
Mutagen
ethyl methanesulfonate
(Newsome et al., 2000)
Progenitor genotype
Cytology
Description

Amino acid replacement: W54term.

(Newsome et al., 2000)

Mutation is predicted to result in a protein truncated in the first Ig domain (before the catalytic domain).

(Newsome et al., 2000)

Nucleotide substitution: G?A.

(Newsome et al., 2000)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3L:12,736,121..12,736,121 [+]
Nucleotide change:

G12736121A

Reported nucleotide change:

G?A

Amino acid change:

W54term | Ptp69D-PA; W54term | Ptp69D-PB

Reported amino acid change:

W54term

Comment:

G to A nucleotide change at the second or third position of the Trp codon leads to a nonsense mutation (exact site of mutation unspecified).

(Newsome et al., 2000)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      At 25oC, the survival rates of homozygotes are: adult survival - 0%, eclosion - 5%, pupation 26%.

      (Desai and Purdy, 2003)

      Mutant R7 axons show targeting defects.

      (Maurel-Zaffran et al., 2001)

      Photoreceptor fates are correctly specified, but their axons project abnormally into the optic lobes in homozygous clones in the eye.

      (Newsome et al., 2000)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressed by
      Statement
      Reference

      Ptp69DD1689 has photoreceptor cell R7 & axon | somatic clone phenotype, suppressible by Lar::Ptp69DLP.GMR.Tag:SS(wg),Tag:HA

      (Maurel-Zaffran et al., 2001)

      Ptp69DD1689 has photoreceptor cell R7 & axon | somatic clone phenotype, suppressible by Lar::Ptp69DPL.GMR.Tag:SS(wg),Tag:HA

      (Maurel-Zaffran et al., 2001)

      Ptp69DD1689 has photoreceptor cell R7 & axon | somatic clone phenotype, suppressible by LarGMR.Tag:SS(wg),Tag:HA

      (Maurel-Zaffran et al., 2001)
      Additional Comments
      Genetic Interactions
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      D1689
      (Newsome et al., 2000)
      PTP69Dd1689
      (Cameron et al., 2013)
      Ptp69DD1689
      (Kurusu and Zinn, 2008)
      Y100
      (Desai and Purdy, 2003)
      Name Synonyms
      Secondary FlyBase IDs
        References (5)