FlyBase Allele Report: Dmel\fng[EP3082]

General Information

Symbol

Dmel\fng^EP3082

Species

D. melanogaster

Name

FlyBase ID

FBal0103826

Feature type

allele

Associated gene

Dmel\fng

Associated Insertion(s)

P{EP}fng^EP3082

Carried in Construct

Also Known As

EP(3)3082, EP-fringe

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Milan and Cohen, 2003, Tseng and Hariharan, 2002, Gene Disruption Project members, 2001-, Milan et al., 2001, Milan et al., 2001, O'Keefe and Thomas, 2001, Milan and Cohen, 2000, Milan and Cohen, 1999)

Progenitor genotype

Associated Insertion(s)

P{EP}fng^EP3082

Cytology

Description

Allele components

Component

Use(s)

Inserted element

P{EP}

misexpression element

Regulatory region(s)

UAS

binary expression system - regulatory region

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

3L:20,949,734..20,949,734 [-]

(Singh et al., 2005, Milan and Cohen, 2003, Tseng and Hariharan, 2002, Gene Disruption Project members, 2001-, Milan et al., 2001, Milan et al., 2001, O'Keefe and Thomas, 2001, Milan and Cohen, 2000, Milan and Cohen, 1999)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible, with Scer\GAL4^en-e16E

(Tseng and Hariharan, 2002)

visible, with Scer\GAL4^ey.PH

(Singh et al., 2005, Tseng and Hariharan, 2002)

Phenotype Manifest In

eye, with Scer\GAL4^ey.PH

(Singh et al., 2005, Tseng and Hariharan, 2002)

wing, with Scer\GAL4^en-e16E

(Tseng and Hariharan, 2002)

Detailed Description

Statement

Reference

Expression of fng^EP3082 under the control of Scer\GAL4^ey.PH results in a small eye.

(Singh et al., 2005)

Expression of fng^EP3082 under the control of Scer\GAL4^ey.PH results in eyes that are strongly reduced in size. Flies expressing fng^EP3082 under the control of Scer\GAL4^hs.2sev have wild-type eyes. Flies expressing fng^EP3082 under the control of Scer\GAL4^en-e16E have reduced wings.

(Tseng and Hariharan, 2002)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Scer\GAL4^ey.PH, fng^EP3082 has visible phenotype, suppressible by CycE^UAS.cLa, Scer\GAL4^ey.PH

(Tseng and Hariharan, 2002)

Suppressor of

Statement

Reference

fng^EP3082/Scer\GAL4^ey.PH is a suppressor of visible | dominant phenotype of L²

(Singh et al., 2005)

fng^EP3082/Scer\GAL4^ap-md544 is a suppressor | partially of visible phenotype of ap^md544/ap^UGO35

(Milan et al., 2001)

fng^EP3082/Scer\GAL4^Bx-hdpR590 is a suppressor of visible | recessive phenotype of Bx^hdpR590

(Milan and Cohen, 2000)

fng^EP3082/Scer\GAL4^ap-md544 is a suppressor of visible phenotype of ap^md544/ap^UGO35

(Milan and Cohen, 1999)

Other

Statement

Reference

Scer\GAL4^ap-md544, Ser^UAS.cSa, ap^md544/ap^UGO35, fng^EP3082 has visible phenotype

(Milan and Cohen, 1999)

Phenotype Manifest In

Suppressed by

Statement

Reference

Scer\GAL4^ey.PH, fng^EP3082 has eye phenotype, suppressible by CycE^UAS.cLa, Scer\GAL4^ey.PH

(Tseng and Hariharan, 2002)

Suppressor of

Statement

Reference

fng^EP3082/Scer\GAL4^ey.PH is a suppressor of eye | ventral phenotype of L²

(Singh et al., 2005)

fng^EP3082/Scer\GAL4^ap-md544 is a suppressor of wing disc phenotype of ap^md544

(Milan and Cohen, 2003)

fng^EP3082/Scer\GAL4^ap-md544 is a suppressor | partially of wing disc phenotype of ap^rK568/ap^md544

(Milan and Cohen, 2003)

fng^EP3082/Scer\GAL4^ap-md544 is a suppressor | partially of wing margin phenotype of ap^md544/ap^UGO35

(Milan et al., 2001)

fng^EP3082/Scer\GAL4^ap-md544 is a suppressor | partially of wing phenotype of ap^md544/ap^UGO35

(Milan et al., 2001)

fng^EP3082/Scer\GAL4^Bx-hdpR590 is a suppressor of wing phenotype of Bx^hdpR590

(Milan and Cohen, 2000)

fng^EP3082/Scer\GAL4^ap-md544 is a suppressor of wing phenotype of ap^md544/ap^UGO35

(Milan and Cohen, 1999)

fng^EP3082/Scer\GAL4^ap-md544 is a suppressor of wing margin bristle phenotype of ap^md544/ap^UGO35

(Milan and Cohen, 1999)

NOT Suppressor of

Statement

Reference

fng^EP3082/Scer\GAL4^ap-md544 is a non-suppressor of wing disc phenotype of ap^md544/ap^UGO35

(Milan and Cohen, 2003)

fng^EP3082/Scer\GAL4^ap-md544 is a non-suppressor of dorsal-ventral compartment boundary of the wing disc phenotype of ap^md544/ap^UGO35

(Milan et al., 2001)

fng^EP3082/Scer\GAL4^ap-md544 is a non-suppressor of dorsal-ventral compartment boundary of the wing disc phenotype of ap^rK568/ap^md544

(Milan et al., 2001)

Other

Statement

Reference

Scer\GAL4^ap-md544, ap^md544/ap^UGO35, fng^EP3082 has wing vein | dorsal phenotype

(Milan et al., 2001)

Scer\GAL4^ap-md544, ap^md544/ap^UGO35, fng^EP3082 has alula | dorsal phenotype

(Milan et al., 2001)

Scer\GAL4^ap-md544, ap^md544/ap^UGO35, fng^EP3082 has wing margin | anterior | dorsal phenotype

(Milan et al., 2001)

Scer\GAL4^ap-md544, Ser^UAS.cSa, ap^md544/ap^UGO35, fng^EP3082 has wing phenotype

(Milan and Cohen, 1999)

Scer\GAL4^ap-md544, ap^md544/ap^UGO35, fng^EP3082 has wing disc phenotype

(Milan and Cohen, 1999)

Scer\GAL4^ap-md544, ap^md544/ap^UGO35, fng^EP3082 has wing margin bristle | ectopic phenotype

(Milan and Cohen, 1999)

Additional Comments

Genetic Interactions

Statement

Reference

Co-expression of CycE^Scer\UAS.cLa suppresses the small eye phenotype caused by expression of fng^EP3082 under the control of Scer\GAL4^ey.PH.

(Tseng and Hariharan, 2002)

Expression of fng^EP3082 under the control of Scer\GAL4^ap-md544 does not restore a smooth boundary between the dorsal and ventral cells in ap^md544/ap^UGO35 wing discs.

(Milan et al., 2001)

Growth of the wing and wing margin formation can be restored in ap^md544/ap^UGO35 flies expressing fng^EP3082 under the control of Scer\GAL4^ap-md544. Both surfaces of the wing differentiate ventral structures; the anterior wing margin and alula differentiate ventral bristles on both surfaces and the pattern of vein corrugation is ventral. Co-expression of fng^EP3082 and Dr^Scer\UAS.cIa under the control of Scer\GAL4^ap-md544 in ap^md544/ap^UGO35 flies results in dorsal differentiation in bristles of the dorsal anterior wing margin.

(Milan et al., 2001)

ap^rK568/ap^md544 flies expressing fng^EP3082 under the control of Scer\GAL4^ap-md544 have wing margin defects.

(O'Keefe and Thomas, 2001)

The severity of the Bx^hdpR590/Y wing phenotype is partially suppressed by expression of fng^EP3082 under the control of Scer\GAL4^Bx-hdpR590.

(Milan and Cohen, 2000)

Expression of fng^EP3082 under the control of Scer\GAL4^ap-md544 rescues the phenotype of ap^md544/ap^UGO35 flies. Patches of ectopic wing margin form and can be associated with outgrowth of the wing. Cells appear to violate the dorsoventral boundary in ap^md544/ap^UGO35 wing discs which are also expressing fng^EP3082 under the control of Scer\GAL4^ap-md544. Expression of both Ser^Scer\UAS.cSa and fng^EP3082 under the control of Scer\GAL4^ap-md544 in ap^md544/ap^UGO35 flies results in well-developed wings which differentiate ventral features on both surfaces; the wing margin, veins and sense organs on the topologically dorsal surface have exclusively ventral identity.

(Milan and Cohen, 1999)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

EP(3)3082

(Milan and Cohen, 2003, O'Keefe and Thomas, 2001, Milan and Cohen, 2000, Milan and Cohen, 1999)

fng^EP3082

Name Synonyms

Secondary FlyBase IDs

References (9)

Report Sections

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