FlyBase Allele Report: Dmel\msl-1[Δ84.Tag:FLAG]

General Information

Symbol

Dmel\msl-1^{Δ84.Tag:FLAG}

Species

D. melanogaster

Name

FlyBase ID

FBal0103657

Feature type

allele

Associated gene

Dmel\msl-1

Associated Insertion(s)

Carried in Construct

P{FΔ84.msl-1}

Key Links

Transgenic product class

inframe_deletion

(Scott et al., 2000)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

inframe_deletion

(Scott et al., 2000)

Mutagen

in vitro construct

(Scott et al., 2000)

Progenitor genotype

msl-1^Δ84.hs

(Scott et al., 2000)

Carried in construct

P{FΔ84.msl-1}

Cytology

Description

The Tag:FLAG tag has been placed at the N terminus.

(Scott et al., 2000)

Allele components

Component

Use(s)

Regulatory region(s)

Hsp70

Encoded product / tool

msl-1

Tagged with

Tag:FLAG

epitope tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | male limited

(Scott et al., 2000)

Phenotype Manifest In

Detailed Description

Statement

Reference

There is a complete loss of male viability in homozygous mutants where expression of msl-1^{Δ84.T:Zzzz\FLAG} in induced by heatshock. There is a partial loss of male viability (about 2/5 of expected males survive) in heterozygous mutants where expression of msl-1^{Δ84.T:Zzzz\FLAG} in induced by milder heatshock. The addition of msl-1^γ269 has no significant affect on the loss of male viability. The addition of msl-2^Hsp83.PK suppresses the male viability phenotype seen in heatshocked msl-1^{Δ84.T:Zzzz\FLAG} flies.

(Scott et al., 2000)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Enhanced by

Statement

Reference

msl-1^{Δ84.Tag:FLAG} has phenotype, enhanceable by msl-2^γ136

(Scott et al., 2000)

NOT Enhanced by

Statement

Reference

msl-1^{Δ84.Tag:FLAG} has phenotype, non-enhanceable by mle¹³

(Scott et al., 2000)

msl-1^{Δ84.Tag:FLAG} has phenotype, non-enhanceable by msl-3¹

(Scott et al., 2000)

Suppressed by

Statement

Reference

msl-1^{Δ84.Tag:FLAG} has phenotype, suppressible by msl-2^Hsp83.PK

(Scott et al., 2000)

NOT suppressed by

Statement

Reference

msl-1^{Δ84.Tag:FLAG} has phenotype, non-suppressible by mle¹³

(Scott et al., 2000)

msl-1^{Δ84.Tag:FLAG} has phenotype, non-suppressible by msl-3¹

(Scott et al., 2000)

Additional Comments

Genetic Interactions

Statement

Reference

The addition of mle¹³ or msl-3¹ has no significant affect on the loss of male viability. The addition of msl-2^γ136 reduces male viability to less than 1/10th of that expected.

(Scott et al., 2000)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

msl-1^{Δ84.T:Zzzz\FLAG}

msl-1^{Δ84.Tag:FLAG}

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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