FlyBase Allele Report: Dmel\Myc[P1]

General Information

Symbol

Dmel\Myc^P1

Species

D. melanogaster

Name

FlyBase ID

FBal0100371

Feature type

allele

Associated gene

Dmel\Myc

Associated Insertion(s)

P{P-Sal-ΔP1}Myc^P1

Carried in Construct

Also Known As

dmyc^P1

Key Links

Allele class

hypomorphic allele - genetic evidence

Mutagen

P-element activity

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Johnston et al., 1999)

Mutagen

P-element activity

(Johnston et al., 1999)

Progenitor genotype

Myc^P0

(Johnston et al., 1999)

Associated Insertion(s)

P{P-Sal-ΔP1}Myc^P1

Cytology

Description

Internal deletion of the P{P-Sal} element.

(Johnston et al., 1999)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal size

(Moberg et al., 2004)

female sterile

(Johnston et al., 1999)

female sterile | recessive

(Quinn et al., 2004)

lethal | female limited

(Kappes et al., 2011)

partially lethal

(Johnston et al., 1999)

radiation sensitive | recessive

(Jaklevic et al., 2006)

visible

(Johnston et al., 1999)

Phenotype Manifest In

adult

(Johnston et al., 1999)

macrochaeta

(Johnston et al., 1999)

oocyte | oogenesis stage S11

(Quinn et al., 2004)

wing

(Johnston et al., 1999)

wing disc posterior compartment

(Johnston et al., 1999)

Detailed Description

Statement

Reference

Approximately 23% of dm^P0 homozygous females survive to adulthood, compared with 51% of sibling dm¹/Y males.

(Kappes et al., 2011)

Irradiation of mutant eye discs with 5 or 10 Gy results in fewer apoptotic cells than irradiation of wild-type discs, although irradiation of eye discs with 50 Gy results in a high number of apoptotic cells in both wild-type and mutant discs.

(Montero et al., 2008)

Homozygous pupae are more sensitive to X rays than wild type or heterozygous sibling controls.

(Jaklevic et al., 2006)

Oogenesis in dm^P1 homozygous females is arrested between stages 10 and 11.

(Quinn et al., 2004)

Stronger phenotype than dm^P0. Thin and shortened bristles. Small body size. Size of wing cells, wing width and wing length are reduced. Number of wing cells may also be reduced. Developmental rate is reduced and flies occasionally have small, roughened eyes. Dissociated wing disc cells are reduced in size compared to wild type. Twin spot analysis of mutant clones shows that dm mutant cells grow very poorly, particularly in the posterior compartment of the wing disc.

(Johnston et al., 1999)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Myc^P1 has lethal | female limited phenotype, suppressible by sisA^unspecified

(Kappes et al., 2011)

Myc^P1 has lethal | female limited phenotype, suppressible by sc^sisB-1

(Kappes et al., 2011)

Myc^P1 has lethal | female limited phenotype, suppressible by run³

(Kappes et al., 2011)

NOT suppressed by

Statement

Reference

Myc^P1 has abnormal size phenotype, non-suppressible by ago^unspecified

(Moberg et al., 2004)

Suppressor of

Statement

Reference

Myc^P1 is a suppressor of viable phenotype of Sxl^fP7B0

(Kappes et al., 2011)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Approximately 84% of sisA^unspecified dm^P1 trans-heterozygous female offspring from dm^P1 fathers mated to sisA^unspecified mothers survive.

Approximately 76% of sc^sisB-1 dm^P1 trans-heterozygous female offspring from dm^P1 fathers mated to sc^sisB-1 mothers survive.

Approximately 89% of run³ dm^P1 trans-heterozygous female offspring from dm^P1 fathers mated to run³ mothers survive.

Females trans-heterozygous for Sxl^fP7B0 and dm^P1 are approximately two-thirds as viable as their dm^P1/+ siblings.

(Kappes et al., 2011)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Myc^P1 is rescued by Myc^UAS.cZa/Scer\GAL4^C-765

(Johnston et al., 1999)

Myc^P1 is rescued by Myc^UAS.cZa/Scer\GAL4^sca-109-68

(Johnston et al., 1999)

Myc^P1 is rescued by Myc^hs.PSA

(Johnston et al., 1999)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Alleles can be ranked in a phenotypic series. Going from weakest to strongest phenotype: dm¹ < dm^P0 < dm^P1.

(Johnston et al., 1999)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

Myc^P1

(Scott et al., 2004)

dm^P1

(Kappes et al., 2011)

dmyc^P1

(Montero et al., 2008, Johnston et al., 1999)

dmyc^p1

(Jaklevic et al., 2006)

Name Synonyms

Secondary FlyBase IDs

References (7)

Report Sections

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