FB2024_03 , released June 25, 2024
Allele: Dmel\agounspecified
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General Information
Symbol
Dmel\agounspecified
Species
D. melanogaster
Name
FlyBase ID
FBal0155659
Feature type
allele
Associated gene
Dmel\ago
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In

        follicle cell & nucleus | somatic clone

        (Shcherbata et al., 2004)
        Detailed Description
        Statement
        Reference

        agounspecified homozygous somatic clones in the ovarian follicle cells show no difference in growth rate compared to their wild-type sister (twin-spot) clones. BrdU incorporation and cell cycle marker expression is normal before stage 6 of oogenesis in these clones, and arrest of the mitotic cycle at stage 6 occurs normally. However, post stage 6 these cells have smaller nuclei and show much reduced BrdU incorporation compared to wild-type. At later stages, localised amplification of DNA fails to occur normally and some clone cells appear apoptotic.

        (Shcherbata et al., 2004)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Suppressor of
        Statement
        Reference

        ago[+]/agounspecified is a suppressor of visible phenotype of CycEJP

        (Brumby et al., 2004)
        NOT Suppressor of
        Statement
        Reference

        agounspecified is a non-suppressor of abnormal size phenotype of MycP0

        (Moberg et al., 2004)

        agounspecified is a non-suppressor of abnormal size phenotype of MycP1

        (Moberg et al., 2004)
        Other
        Phenotype Manifest In
        Suppressor of
        Statement
        Reference

        ago[+]/agounspecified is a suppressor of eye phenotype of CycEJP

        (Brumby et al., 2004)
        Other
        Statement
        Reference

        CSN4unspecified, agounspecified has nurse cell phenotype

        (Doronkin et al., 2003)

        CSN4unspecified, agounspecified has nurse cell & nucleus phenotype

        (Doronkin et al., 2003)

        CSN4unspecified/CSN4[+], agounspecified has nurse cell phenotype

        (Doronkin et al., 2003)

        CSN4unspecified/CSN4[+], agounspecified has nurse cell & nucleus phenotype

        (Doronkin et al., 2003)

        CSN4unspecified, ago[+]/agounspecified has nurse cell phenotype

        (Doronkin et al., 2003)

        CSN4unspecified, ago[+]/agounspecified has nurse cell & nucleus phenotype

        (Doronkin et al., 2003)
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        Unlike either single heterozygote, ovaries from CSN4unspecified; agounspecified transheterozygous females exhibit ectopic cell death and increased or decreased nurse cells per egg chamber. Decreased nurse cell numbers per cyst are accompanied by an increase in nurse cell ploidy, suggesting that the decrease results from a block in cell division without a block in DNA replication. In addition, strongly DAPI staining regions of nurse cell nuclei (which may respond to compact heterochromatin) are enlarged compared to wild-type.

        (Doronkin et al., 2003)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        agounspecified
        Name Synonyms
        Secondary FlyBase IDs
          References (4)