FlyBase Allele Report: Dmel\sens[E58]

General Information

Symbol

Dmel\sens^E58

Species

D. melanogaster

Name

FlyBase ID

FBal0098020

Feature type

allele

Associated gene

Dmel\sens

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

loss of function allele

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

loss of function allele

(Parrish et al., 2006, Nolo et al., 2001)

Mutagen

ethyl methanesulfonate

(Bloomington Drosophila Stock Center, 1999.7.3)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy

(Parrish et al., 2006)

lethal | recessive

(Bloomington Drosophila Stock Center, 1999.7.3)

Phenotype Manifest In

abdominal dorsal multidendritic neuron ddaE & dendrite

(Parrish et al., 2006)

dorsal multidendritic neuron ddaE & dendrite

(Parrish et al., 2006)

embryonic/larval salivary gland

(Chandrasekaran and Beckendorf, 2003)

Detailed Description

Statement

Reference

In sens^E58 mutants, one of the dorsal class I neurons is missing in most hemisegments. In the remaining class I neurons, dendrites overextend dorsally and the arbors of ddaD and ddaE neurons are often mixed.

(Parrish et al., 2006)

Heterozygotes do not show a loss of wing margin phenotype.

(Nolo et al., 2001)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

sens^E58/sens[+] is a suppressor | partially of visible phenotype of mir-9a^J22

(Li et al., 2006)

Phenotype Manifest In

Suppressor of

Statement

Reference

sens^E58/sens[+] is a suppressor | partially of mechanosensory chaeta | increased number | adult stage phenotype of Rbfox1^RNAi.UAS, Scer\GAL4^sca-109-68

(Shukla et al., 2017)

sens^E58/sens[+] is a suppressor | partially of scutellar bristle | increased number phenotype of TBPH^Q367X

(Li et al., 2013)

sens^E58/sens[+] is a suppressor | partially of wing margin phenotype of mir-9a^J22

(Li et al., 2006)

Additional Comments

Genetic Interactions

Statement

Reference

Heterozygosity for sens^E58 partially suppresses the supernumerary thoracic sensory bristle phenotype of individuals expressing Rbfox1^{dsRNA.Scer\UAS} under the control of Scer\GAL4^sca-109-68.

(Shukla et al., 2017)

The presence of the sens^E58/+ mutation partially rescues the supernumerary bristle phenotype of TBPH^Q367X/TBPH^Q367X mutants.

(Li et al., 2013)

One copy of sens^E58 substantially rescues the wing margin defects of mir-9a^J22 homozygotes; about 30% of the double mutant flies have wings that are indistinguishable from wild type, while others lack only a small part of the posterior margin. The bristles on the anterior wing margin resemble wild type in the double mutant flies.

(Li et al., 2006)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Complements

sens^SX67

(Nolo et al., 2001)

Fails to complement

sens^SX67R12

(Nolo et al., 2001)

sens^E1