FB2024_03 , released June 25, 2024
Allele: Dmel\sensLy-1
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General Information
Symbol
Dmel\sensLy-1
Species
D. melanogaster
Name
FlyBase ID
FBal0011759
Feature type
allele
Associated gene
Dmel\sens
Associated Insertion(s)
Carried in Construct
Also Known As
Ly1
Key Links
Allele class

gain of function allele

Mutagen
Nature of the Allele
Allele class

gain of function allele

(Nolo et al., 2001)
Mutagen
X ray
Progenitor genotype
Caused by aberration
Df(3L)Ly
Cytology
Description

Distal breakpoint affects a genomic fragment containing the 3' end, including the 3' untranslated region, of sens.

(Nolo et al., 2001)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Heterozygotes show loss of both anterior and posterior wing margin.

      Ectopic cell death is not seen in the wing discs of heterozygous animals.

      (Bejarano et al., 2010)

      sensLy-1 in combination with a "sens" allele of sens results in either no loss of PNS neurons in embryos or a very subtle loss. sensSX67 interacts additively with sensLy-1 to produce a more severe wing margin loss.

      (Nolo et al., 2001)

      Wing anterior and posterior margins are missing.

      (Abbott and Sprey, 1990)

      Lateral margins of wings excised, giving narrowed shape; angle between veins L2 and L5 reduced. Bristles shortened and stubby; postscutellars frequently missing. Eyes somewhat deformed with tufted vibrissae. Abdomen dark and narrow with rear edge of tergites raised. Homozygous lethal. sens/Df(3L)M69E is lethal. Modification of wings first visible as marginal scalloping of prepupal wing buds; wing fold narrower (Waddington, 1939; Waddington, 1940). RK1A.

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhanced by
      Statement
      Reference

      sensLy-1 has wing phenotype, enhanceable by sdETX4

      (Srivastava and Bell, 2003)
      NOT suppressed by
      Statement
      Reference

      sensLy-1 has phenotype, non-suppressible by su(Hw)2

      (Lindsley and Grell, 1968)
      Enhancer of
      Statement
      Reference

      sensLy-1 is an enhancer of wing phenotype of sdETX4

      (Srivastava and Bell, 2003)
      Suppressor of
      Statement
      Reference

      sensLy-1/sens[+] is a suppressor of wing vein | ectopic phenotype of Snr1E1

      (Marenda et al., 2004)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (1)
      Stocks (35)
      Notes on Origin
      Discoverer

      Dubinin, 1929.

      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      Ly1
      (Bejarano et al., 2010, Marenda et al., 2004, Srivastava and Bell, 2003, Lindsley and Zimm, 1992)
      Lyra
      (Cohen et al., 2006)
      sensLy-1
      sensLyra
      (Jafar-Nejad and Bellen, 2004)
      Name Synonyms
      Lyra
      (Bejarano et al., 2010)
      Secondary FlyBase IDs
        References (12)