FlyBase Allele Report: Dmel\tim[rit]

General Information

Symbol

Dmel\tim^rit

Species

D. melanogaster

Name

FlyBase ID

FBal0097897

Feature type

allele

Associated gene

Dmel\tim

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Cytology

Description

Amino acid replacement: P1093A. Nucleotide substitution: C3492G.

(Matsumoto et al., 1999)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

2L:3,500,064..3,500,064 [-]

Nucleotide change:

C3500064G

Reported nucleotide change:

C3492G

Amino acid change:

Reported amino acid change:

P1093A

(Matsumoto et al., 1999)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal circadian rhythm

(Matsumoto et al., 1999)

abnormal locomotor rhythm

(Matsumoto et al., 1999)

Phenotype Manifest In

Detailed Description

Statement

Reference

Alters free-running periods in a temperature-dependent manner. After entrainment to LD12:12 at 24^oC mutants show a lengthened circadian rhythm under DD, by about 2 hours. When the temperature is elevated the length of the period increases. At 30^o the period length is 10 hours longer than wild type. At 30^oC many flies show arrhythmicity.

(Matsumoto et al., 1999)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Enhanced by

Statement

Reference

tim^rit has phenotype, enhanceable by per^L1

(Matsumoto et al., 1999)

NOT Enhanced by

Statement

Reference

tim^rit has phenotype, non-enhanceable by per^s

(Matsumoto et al., 1999)

Suppressed by

Statement

Reference

tim^rit has phenotype, suppressible by Dp(1;2;Y)w⁺

(Matsumoto et al., 1999)

NOT suppressed by

Statement

Reference

tim^rit has phenotype, non-suppressible by per^s

(Matsumoto et al., 1999)

Enhancer of

Statement

Reference

tim^rit is an enhancer of phenotype of per^L1

(Matsumoto et al., 1999)

NOT Enhancer of

Statement

Reference

tim^rit is a non-enhancer of phenotype of per^s

(Matsumoto et al., 1999)

NOT Suppressor of

Statement

Reference

tim^rit is a non-suppressor of phenotype of per^s

(Matsumoto et al., 1999)

Additional Comments

Genetic Interactions

Statement

Reference

per^L1, tim^rit double mutants show a period length of 32.9hr at 24^oC, which exceeds that expected for the summation of the individual effects. At 27^oC the period is 44.4hr. per^s, tim^rit double mutants show a period length that represents the additive effect of the two single mutants. A per gene dosage of 2 (as in Dp(1;2;Y)w⁺/+ males) completely restores wild type behavior to tim^rit mutants. A per gene dosage of 1.5 (as in Dp(1;2;Y)w⁺/attached X females) partly restores wild type behavior to tim^rit mutants.

(Matsumoto et al., 1999)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

tim⁰¹

(Matsumoto et al., 1999)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

rit

(Matsumoto et al., 1999)

tim^rit

(Singh et al., 2019)

tim^ritsu

(Stanewsky, 2003)

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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