FB2024_03 , released June 25, 2024
Allele: Dmel\SxlFLΔ.Hsp83
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General Information
Symbol
Dmel\SxlFLΔ.Hsp83
Species
D. melanogaster
Name
FlyBase ID
FBal0097100
Feature type
allele
Associated gene
Dmel\Sxl
Associated Insertion(s)
Carried in Construct
P{Hsp83-Sxl.FLΔ-MS3}
Key Links
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Yanowitz et al., 1999)
Progenitor genotype
SxlFL.Hsp83
(Yanowitz et al., 1999)
Carried in construct
P{Hsp83-Sxl.FLΔ-MS3}
Cytology
Description

3'UTR has been truncated to remove 8 out of 10 of the putative Sxl binding sites.

(Yanowitz et al., 1999)
Allele components
Component
Use(s)
Regulatory region(s)
Hsp83
Encoded product / tool
Sxl
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Extra pole cells are evident in embryos derived from SxlFLΔ.Hsp83 mothers at all stages of development. Germ cells show migration defects, beginning at stage 10. Early defects include failure to contact gonadal mesoderm and premature clumping. Later phenotypes include lack of sustained contact with presumptive gonadal mesoderm and failure to coalesce. Germ cells can be small and irregularly shaped. These defects are not sex-specific.

      (Deshpande et al., 1999)

      Males are killed by a single copy of the P{Hsp83-Sxl.FLΔ-MS3} transgene. Male killing activity is greater than for the parental allele, SxlFL.Hsp83, but the effect is only revealed in particular genetic backgrounds, since the lethality caused by SxlFL.Hsp83 is complete. Male killing activity does not depend on a functional Sxl product.

      (Yanowitz et al., 1999)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      NOT suppressed by
      Statement
      Reference

      SxlFLΔ.Hsp83 has phenotype, non-suppressible by msl-2Hsp83.PK

      (Yanowitz et al., 1999)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The few SxlFLΔ.Hsp83/SxlfP7B0 males rescued to viability by msl-2Hsp83.PK show intersex characteristics. They have lighter abdominal pigmentation, rotated genitalia, fewer sex combs and are sterile.

      (Yanowitz et al., 1999)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescues

      SxlFLΔ.Hsp83 partially rescues Sxlf2593

      (Yanowitz et al., 1999)

      SxlFLΔ.Hsp83 partially rescues Sxlf7,M1

      (Yanowitz et al., 1999)
      Fails to rescue

      SxlFLΔ.Hsp83 fails to rescue SxlM1,f3

      (Yanowitz et al., 1999)
      Comments

      Rescue of Sxlf2593 by SxlFL.Hsp83 is more effective than that by SxlFLΔ.Hsp83 or SxlNΔ.Hsp83.

      (Yanowitz et al., 1999)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      SxlFLΔ.Hsp83
      Name Synonyms
      Secondary FlyBase IDs
        References (2)