FB2024_03 , released June 25, 2024
Allele: Dmel\Sxlf2593
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General Information
Symbol
Dmel\Sxlf2593
Species
D. melanogaster
Name
FlyBase ID
FBal0016687
Feature type
allele
Associated gene
Dmel\Sxl
Associated Insertion(s)
Carried in Construct
Also Known As
Sxl2593
Key Links
Allele class

loss of function allele

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Lindsley and Zimm, 1992)

loss of function allele

(Maine et al., 1985)
Mutagen
ethyl methanesulfonate
(Lindsley and Zimm, 1992, Maine et al., 1985)
Progenitor genotype
Cytology
Description

Probably point mutation (no gross alteration in DNA).

(Maine et al., 1985)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Temperature-sensitive for most Sxl functions. Perhaps most notable for the fact that homozygote viability can be quite high, with females developing as true intersexes (their specific grade of intersexuality depends on temperature). Lethal over a deficiency, a null allele, or Sxlf7,M1 at any temperature; at permissive temperatures, weakly complements SxlM1,f3 and hypomorphic alleles of the "SxlfPR" class, generating (true) intersexual escapers; complementation better with SxlfPb, generating sterile females; fully complements Sxlf2, Sxlf9 and Sxlfhv1. temperature-sensitive for variety of functions; escapers masculinized to variable degree.

      (Lindsley and Zimm, 1992)

      At 25oC females have high viability but are masculinised. P{SxlcF1} construct can feminise the females.

      (Bell et al., 1991)

      Homozygous XX flies show a high degree of lethality, the survivors are intersex. Homozygous germ cell clones give rise to functional eggs. Viability is greatly reduced in heterozygous combination with Df(1)N71 or Df(1)svr.

      (Granadino et al., 1991)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Complements

      Sxlfhv1

      (Lindsley and Zimm, 1992)

      Sxlf9

      (Lindsley and Zimm, 1992)

      Sxlf2

      (Lindsley and Zimm, 1992)
      Partially complements

      SxlM1,f3

      (Lindsley and Zimm, 1992)
      Fails to complement

      Sxlf7,M1

      (Lindsley and Zimm, 1992)
      Partially rescued by

      Sxlf2593 is partially rescued by SxlNΔ.Hsp83

      (Yanowitz et al., 1999)

      Sxlf2593 is partially rescued by SxlFL.Hsp83

      (Yanowitz et al., 1999)

      Sxlf2593 is partially rescued by SxlFLΔ.Hsp83

      (Yanowitz et al., 1999)
      Comments

      Females rescued by SxlFL.Hsp83 are intersexual. Females rescued by SxlFLΔ.Hsp83 are completely feminized.

      (Yanowitz et al., 1999)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Clonal analysis demonstrates that Sxlf2593 directly affects the late Sxl function required continuously during development of the female cells.

      (Granadino et al., 1991)

      Nuclei of homozygous larvae and heteroallelic combinations with SxlfPb and SxlfLS exhibit binding of the msl gene products to the paired X chromosomes but no Sxl binding.

      (Hilfiker et al., 1994)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Sxl2593
      (Meller et al., 1997, Lindsley and Zimm, 1992, Salz et al., 1987, Maine et al., 1985)
      Sxlf2593
      Name Synonyms
      Secondary FlyBase IDs
        References (11)