FB2024_03 , released June 25, 2024
Allele: Dmel\cutletrJ865a
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General Information
Symbol
Dmel\cutletrJ865a
Species
D. melanogaster
Name
FlyBase ID
FBal0086666
Feature type
allele
Associated gene
Dmel\cutlet
Associated Insertion(s)
P{PZ}cutletrJ865a
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Jaffe and Jongens, 2001, Jaffe and Jongens, 1998)
Progenitor genotype
Associated Insertion(s)
P{PZ}cutletrJ865a
Cytology
Description

P{PZ} insertion after nucleotide 115 of the cutlet transcript. The insertion disrupts the 4th amino acid after the putative initiator methionine. The P{PZ} element is inserted in the opposite orientation to that of the cutlet transcript.

(Jaffe and Jongens, 2001)
Allele components
Component
Use(s)
Inserted element
P{PZ}
Encoded product / tool
lacZ
Tagged with
Tag:NLS(P)
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The penetrance of the female sterile and rough eye phenotypes in cutletrJ865a/Df(2L)ed1 flies is more than 99%. The penetrance of the wing phenotype is 38%. Homozygous eyes contain numerous ommatidial clusters with less than the normal number of photoreceptor cells. The positions of the missing cells suggest that they correspond to presumptive photoreceptors R1, R6 and R7. Homozygous clones grow more slowly than their wild-type twin spots in the eye, wing and leg discs.

      (Jaffe and Jongens, 2001)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhanced by
      Statement
      Reference

      cutletrJ865a has visible | recessive phenotype, enhanceable by RfC38k13807/RfC38[+]

      (Jaffe and Jongens, 2001)
      Phenotype Manifest In
      Enhanced by
      Statement
      Reference

      cutletrJ865a has ommatidium phenotype, enhanceable by RfC38k13807/RfC38[+]

      (Jaffe and Jongens, 2001)

      cutletrJ865a has eye photoreceptor cell phenotype, enhanceable by RfC38k13807/RfC38[+]

      (Jaffe and Jongens, 2001)

      cutletrJ865a has ommatidium phenotype, enhanceable by RfC40[+]/RfC4B6

      (Jaffe and Jongens, 2001)

      cutletrJ865a has eye photoreceptor cell phenotype, enhanceable by RfC40[+]/RfC4B6

      (Jaffe and Jongens, 2001)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The cutletrJ865a eye phenotype is enhanced by one copy of RfC40B6 or RfC38k13807; the majority of ommatidial clusters in these flies have an abnormal number of photoreceptor cells and a large number of ommatidia are fused.

      (Jaffe and Jongens, 2001)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      cutletunspecified

      (Jaffe and Jongens, 2001)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Induced with: P{PZ}rJ865b. The recessive lethal "l(2)rJ865" line originally contained two P{PZ} insertions; P{PZ}cutletrJ865a at 24B1--24B2 and the putatively lethal P{PZ}rJ865b insertion at 33E7--33E8.

      (Jaffe and Jongens, 2001)
      Comments
      Comments

      Excision of the P{PZ} element can revert the phenotype to wild type.

      (Jaffe and Jongens, 2001)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      cutletP1
      (Jaffe and Jongens, 2001)
      cutletrJ865a
      Name Synonyms
      gilead
      (Jaffe and Jongens, 1998)
      Secondary FlyBase IDs
        References (2)