FB2024_03 , released June 25, 2024
Allele: Dmel\eve5
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General Information
Symbol
Dmel\eve5
Species
D. melanogaster
Name
FlyBase ID
FBal0086630
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Nature of the Allele
Allele class
Progenitor genotype
Cytology
Description

Deletion starting from the first base of codon 255 and ending at the second base of codon 326, resulting in deletion and frameshift mutations from amino acids 255 to 376 (the C-terminus of wild-type eve).

200-300bp deletion in the 3' end of the coding region.

Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Comment:

Deletion starting from the first base of codon 255 and ending at the second base of codon 326, resulting in a frameshift and translation termination after the addition of 48 novel amino acids. Position of mutation on reference sequence inferred by FlyBase curator based on author statement.

Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In

larval brain & neuroblast (with eve1)

Detailed Description
Statement
Reference

eve1/eve5 larval brains show a significant reduction in normalised proliferation compared to controls.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement
Reference

eve[+]/eve5 is an enhancer of partially lethal - majority die phenotype of trol13

Suppressor of
Statement
Reference
Phenotype Manifest In
Enhancer of
Statement
Reference

eve5 is an enhancer of phenotype of trol13

Other
Statement
Reference

eve5, trol13 has larval brain & neuroblast phenotype

Additional Comments
Genetic Interactions
Statement
Reference

Dominantly enhances the semi-lethality of trol13/Y males and shows a transheterozygous effect in trol13/+ females, resulting in a reduction in viability. Neuroblasts in the trolsd larval brain show a proliferation defect. This phenotype is not affected if the larvae are also heterozygous for eve5. Hemizygous trol13 male larvae have a normal number of S phase neuroblasts per brain lobe. If the trol13 larvae are also heterozygous for eve5, then the number of S phase neuroblasts per brain lobe is reduced in 66% of larvae and unaffected in 33% of larvae.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (2)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (4)
Reported As
Name Synonyms
Secondary FlyBase IDs
  • FBal0039562
References (10)