FlyBase Allele Report: Dmel\trx[unspecified]

General Information

Symbol

Dmel\trx^unspecified

Species

D. melanogaster

Name

FlyBase ID

FBal0086282

Feature type

allele

Associated gene

Dmel\trx

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Moore et al., 1998)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | larval stage | somatic clone

(Komori et al., 2014)

Phenotype Manifest In

gonad | precursor

(Moore et al., 1998)

type II neuroblast | larval stage | somatic clone

(Komori et al., 2014)

type I neuroblast | ectopic | larval stage | somatic clone

(Komori et al., 2014)

Detailed Description

Statement

Reference

Type I neuroblasts in homozygous clones in larval brains retain their functional identity (as assayed by expression of cell fate markers). However, mutant type II neuroblasts in the homozygous clones adopt a type I neuroblast identity and directly generate ganglion mother cells.

(Komori et al., 2014)

Many germ cells are able to coalesce along with gonadal mesoderm to form a gonad; however, some germ cells are excluded from this gonad, presumably due to the reduction in number of somatic gonadal precursors (SGPs). These 'lost' germ cells remain in an area ventral and posterior to the gonad until after coalescence.

(Moore et al., 1998)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

trx^unspecified has abnormal neuroanatomy | somatic clone | larval stage phenotype, suppressible by btd^UAS.Tag:HA/Scer\GAL4^unspecified

(Komori et al., 2014)

Enhancer of

Statement

Reference

trx^unspecified is an enhancer of abnormal eye color phenotype of w^ph-p.lac+3/w¹¹¹⁸

(Bloyer et al., 2003)

NOT Enhancer of

Statement

Reference

trx^unspecified is a non-enhancer of neoplasia phenotype of Delta^UAS.cDa, Scer\GAL4^ey.PH, lola^GS88A8, psq^GS88A8

(Ferres-Marco et al., 2006)

trx^unspecified is a non-enhancer of visible phenotype of Delta^UAS.cDa, Scer\GAL4^ey.PH, lola^GS88A8, psq^GS88A8

(Ferres-Marco et al., 2006)

Suppressor of

Statement

Reference

trx^unspecified is a suppressor | somatic clone of abnormal neuroanatomy | somatic clone | larval stage phenotype of erm^unspecified

(Komori et al., 2014)

trx^unspecified is a suppressor | somatic clone of abnormal neuroanatomy | somatic clone | larval stage phenotype of brat^unspecified

(Komori et al., 2014)

trx[+]/trx^unspecified is a suppressor of visible phenotype of Scer\GAL4^Bx-MS1096, esc^RNAi.UAS, escl^RNAi.UAS

(Ohno et al., 2008)

trx^unspecified is a suppressor of lethal phenotype of Ras85D^V12.sev, sev^S11.Tag:MYC

(Maixner et al., 1998)

Other

Statement

Reference

pros¹⁷, trx^unspecified has abnormal neuroanatomy | somatic clone | larval stage phenotype

(Komori et al., 2014)

Ras85D^V12.sev, sev^S11.Tag:MYC, trx^unspecified has viable phenotype

(Maixner et al., 1998)

Phenotype Manifest In

NOT Enhanced by

Statement

Reference

trx^unspecified has phenotype, non-enhanceable by lolal^k02512/lolal[+]

(Mishra et al., 2003)

trx^unspecified has phenotype, non-enhanceable by Iswi^unspecified/Iswi[+]

(Deuring et al., 2000)

trx^unspecified has phenotype, non-enhanceable by Asx^R11

(Milne et al., 1999)

Suppressed by

Statement

Reference

trx^unspecified has type II neuroblast | somatic clone | larval stage phenotype, suppressible by btd^UAS.Tag:HA/Scer\GAL4^unspecified

(Komori et al., 2014)

NOT suppressed by

Statement

Reference

trx^unspecified has phenotype, non-suppressible by lolal^k02512/lolal[+]

(Mishra et al., 2003)

trx^unspecified has phenotype, non-suppressible by Iswi^unspecified/Iswi[+]

(Deuring et al., 2000)

NOT Enhancer of

Statement

Reference

trx^unspecified is a non-enhancer of eye phenotype of Delta^UAS.cDa, Scer\GAL4^ey.PH, lola^GS88A8, psq^GS88A8

(Ferres-Marco et al., 2006)

trx[+]/trx^unspecified is a non-enhancer of phenotype of lolal^k02512

(Mishra et al., 2003)

trx^unspecified is a non-enhancer of embryonic/larval hemocyte phenotype of mxc^G43

(Remillieux-Leschelle et al., 2002)

Suppressor of

Statement

Reference

trx^unspecified is a suppressor | somatic clone of type II neuroblast | increased number | somatic clone | larval stage phenotype of brat^unspecified

(Komori et al., 2014)

trx^unspecified is a suppressor | somatic clone of type II neuroblast | increased number | somatic clone | larval stage phenotype of erm^unspecified

(Komori et al., 2014)

trx[+]/trx^unspecified is a suppressor of wing phenotype of Scer\GAL4^Bx-MS1096, esc^RNAi.UAS, escl^RNAi.UAS

(Ohno et al., 2008)

NOT Suppressor of

Statement

Reference

trx[+]/trx^unspecified is a non-suppressor of phenotype of lolal^k02512

(Mishra et al., 2003)

trx^unspecified is a non-suppressor of embryonic/larval hemocyte phenotype of mxc^G43

(Remillieux-Leschelle et al., 2002)

Other

Statement

Reference

pros¹⁷, trx^unspecified has type I neuroblast | increased number | somatic clone | larval stage phenotype

(Komori et al., 2014)

Additional Comments

Genetic Interactions

Statement

Reference

trx^unspecified suppresses the supernumerary type II neuroblast phenotype seen in erm^unspecified type II neuroblast clones in the larval brain, and the number of GMCs and neurons is significantly increased in the double mutant clone.

trx^unspecified suppresses the supernumerary type II neuroblast phenotype seen in brat^unspecified type II neuroblast clones in the larval brain, and the number of GMCs and neurons is significantly increased in the double mutant clone.

trx^unspecified pros¹⁷ double mutant type II neuroblast clones form supernumerary type I neuroblasts.

Expression of btd^{Scer\UAS.T:Ivir\HA1} using a Scer\GAL4 driver in trx^unspecified type II neuroblast clones in the larval brain restores the ability of the type II neuroblasts to generate intermediate neural progenitors.

(Komori et al., 2014)

The wing defects caused by simultaneous expression of two copies of esc^{dsRNA.Scer\UAS} and escl^{dsRNA.Scer\UAS} under the control of Scer\GAL4^Bx-MS1096 are completely suppressed by trx^unspecified/+.

(Ohno et al., 2008)

trx^unspecified does not enhance the eye tumour phenotype of flies expressing Dl^Scer\UAS.cDa under the control of Scer\GAL4^ey.PH and also carrying the P{GSV1}lola^GS88A8 insertion (which results in the lola^GS88A8 and psq^GS88A8 alleles being expressed under the control of Scer\GAL4^ey.PH).

(Ferres-Marco et al., 2006)

The addition of heterozygous, trx^unspecified to lolal^k02512/+ animals shows enhancement or suppression.

(Mishra et al., 2003)

The lethality caused by sev^{S11.T:Hsap\MYC} in combination with Ras85D^V12.sev is suppressed by trx^unspecified.

(Maixner et al., 1998)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

17 mutants are isolated.

(Moore et al., 1998)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

trx^unspecified

Name Synonyms

Secondary FlyBase IDs

References (10)

Report Sections

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