FlyBase Allele Report: Dmel\beat-Ia[C163]

General Information

Symbol

Dmel\beat-Ia^C163

Species

D. melanogaster

Name

FlyBase ID

FBal0085881

Feature type

allele

Associated gene

Dmel\beat-Ia

Associated Insertion(s)

Carried in Construct

Also Known As

beat^C163

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Caused by aberration

In(2L)C163.41

Cytology

Description

Aberration breakpoint within beat-Ia.

(Ashburner et al., 1999)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal (with Df(2L)BSC278)

(Kahsai and Cook, 2018)

lethal | recessive

(The Moscow Regional Drosophila melanogaster Stock Center, Dubna)

Phenotype Manifest In

Detailed Description

Statement

Reference

beat-Ia^C163/Df(2L)BSC278 results in lethality with escapers.

(Kahsai and Cook, 2018)

beat-Ia³/beat-Ia^C163 third instar larvae often lack neuromuscular junctions (NMJs) on dorsal muscles (the percentage of muscles lacking NMJs is given in parentheses); muscle 1 (31%), muscle 9 (34%), muscle 2 (8%), muscle 10 (13%).

beat-Ia³/beat-Ia^C163 third instar larvae often lack neuromuscular junctions (NMJs) on ventral muscles (the percentage of muscles lacking NMJs is given in parentheses); muscle 12 (25%), muscle 13 (34%), muscle 6 (38%), muscle 7 (55%).

(Siebert et al., 2009)

Leaky allele.

(Ashburner et al., 1999)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhanced by

Statement

Reference

beat-Ia^C163/beat-Ia³, unc-5⁸ has abnormal neuroanatomy phenotype, non-enhanceable by Nrg^l10

(Zarin et al., 2014)

NOT suppressed by

Statement

Reference

beat-Ia^C163/beat-Ia³, unc-5⁸ has abnormal neuroanatomy phenotype, non-suppressible by Nrg^l10

(Zarin et al., 2014)

Enhancer of

Statement

Reference

beat-Ia^C163, Nrg^l10, beat-Ia³ is an enhancer of abnormal neuroanatomy phenotype of unc-5⁸

(Zarin et al., 2014)

beat-Ia^C163/beat-Ia³ is an enhancer of abnormal neuroanatomy phenotype of unc-5⁸

(Zarin et al., 2014)

unc-5[+], beat-Ia^C163, beat-Ia[+], unc-5⁸ is an enhancer of abnormal neuroanatomy phenotype of eve³

(Zarin et al., 2014)

Suppressor of

Statement

Reference

beat-Ia^C163, unc-5⁸, beat-Ia³ is a suppressor | partially of abnormal neuroanatomy phenotype of Scer\GAL4^eg-Mz360, eve^UAS.cBa

(Zarin et al., 2014)

beat-Ia^C163/beat-Ia[+] is a suppressor of abnormal neuroanatomy | embryonic stage phenotype of frac^Δ1

(Miller et al., 2011)

Phenotype Manifest In

NOT Enhanced by

Statement

Reference

beat-Ia^C163/beat-Ia³, unc-5⁸ has motor neuron phenotype, non-enhanceable by Nrg^l10

(Zarin et al., 2014)

beat-Ia^C163/beat-Ia³ has muscle cell of A1-7 dorsal acute muscle 1 phenotype, non-enhanceable by Scer\GAL4^how-24B

(Siebert et al., 2009)

beat-Ia^C163/beat-Ia³ has muscle cell of A1-7 dorsal acute muscle 2 phenotype, non-enhanceable by Scer\GAL4^how-24B

(Siebert et al., 2009)

beat-Ia^C163/beat-Ia³ has muscle cell of A1-7 dorsal oblique muscle 1 phenotype, non-enhanceable by Scer\GAL4^how-24B

(Siebert et al., 2009)

beat-Ia^C163/beat-Ia³ has muscle cell of A1-7 dorsal oblique muscle 2 phenotype, non-enhanceable by Scer\GAL4^how-24B

(Siebert et al., 2009)

beat-Ia^C163/beat-Ia³ has muscle cell of A1-7 dorsal acute muscle 1 phenotype, non-enhanceable by Scer\GAL4^Mef2.PR

(Siebert et al., 2009)

beat-Ia^C163/beat-Ia³ has muscle cell of A1-7 dorsal acute muscle 2 phenotype, non-enhanceable by Scer\GAL4^Mef2.PR

(Siebert et al., 2009)

beat-Ia^C163/beat-Ia³ has muscle cell of A1-7 dorsal oblique muscle 1 phenotype, non-enhanceable by Scer\GAL4^Mef2.PR

(Siebert et al., 2009)

beat-Ia^C163/beat-Ia³ has muscle cell of A1-7 dorsal oblique muscle 2 phenotype, non-enhanceable by Scer\GAL4^Mef2.PR

(Siebert et al., 2009)

NOT suppressed by

Statement

Reference

beat-Ia^C163/beat-Ia³, unc-5⁸ has motor neuron phenotype, non-suppressible by Nrg^l10

(Zarin et al., 2014)

Enhancer of

Statement

Reference

beat-Ia^C163, Nrg^l10, beat-Ia³ is an enhancer of larval intersegmental nerve phenotype of unc-5⁸

(Zarin et al., 2014)

beat-Ia^C163/beat-Ia³ is an enhancer of motor neuron phenotype of unc-5⁸

(Zarin et al., 2014)

unc-5[+], beat-Ia^C163, beat-Ia[+], unc-5⁸ is an enhancer of larval intersegmental nerve phenotype of eve³

(Zarin et al., 2014)

Suppressor of

Statement

Reference

beat-Ia^C163, unc-5⁸, beat-Ia³ is a suppressor | partially of larval EW neuron phenotype of Scer\GAL4^eg-Mz360, eve^UAS.cBa

(Zarin et al., 2014)

beat-Ia^C163/beat-Ia[+] is a suppressor of larval intersegmental nerve branch ISNb of A1-7 | embryonic stage phenotype of frac^Δ1

(Miller et al., 2011)

Additional Comments

Genetic Interactions

Statement

Reference

CNS exit from EW neurons misexpressing eve^Scer\UAS.cBa is partially suppressed in an unc-5⁸ beat-Ia^C163/beat-Ia³ mutant background while midline crossing is partially restored (in 15% of hemisegments).

Nrg^l10/Y; beat-Ia^C163/beat-Ia³ double mutants exhibit intersegmental nerve axon stalling prior to the first branch point.

unc-5⁸, beat-Ia^C163/beat-Ia³ double mutants exhibit intersegmental nerve axon stalling prior to the first branch point.

Nrg^l10/Y; unc-5⁸, beat-Ia^C163/beat-Ia³ triple mutants exhibit severe defects in the intersegmental nerve crossing in the ventral muscle field.

Nrg^l10/Y; beat-Ia^C163/beat-Ia³ double mutants do not exhibit any aCC or RP2 exit phenotypes.

unc-5⁸, beat-Ia^C163/beat-Ia³ mutants exhibit a failure of motor neurons to exit the CNS in 10% of hemisegments.

The addition of a Nrg^l10/Y background does not affect the unc-5⁸, beat-Ia^C163/beat-Ia³ CNS exit failure seen in 10% of unc-5⁸, beat-Ia^C163/beat-Ia³ hemisegments.

A transheterozygous combination of eve³/+, unc-5⁸/+ reduces beat-Ia levels to 50% and significantly increases the defects seen in intersegmental nerves, with the number of axons exhibiting stalling increasing from 8.1% to 23.1% in eve³/+, unc-5⁸/+ transheterozygotes and eve³/+, unc-5⁸/+, beat-Ia^C163/+ triple heterozygotes, respectively.

(Zarin et al., 2014)

A heterozygous beat-Ia^C163 background dominantly suppresses the ISNb pathfinding phenotypes from 64% in frac^Δ1 homozygotes to 18% in double mutants.

(Miller et al., 2011)

The neuromuscular junction innervation defects seen in the dorsal muscles of beat-Ia³/beat-Ia^C163 third instar larvae are not enhanced by expression of side^Scer\UAS.cSa under the control of either Scer\GAL4^how-24B or Scer\GAL4^Mef2.PR.

(Siebert et al., 2009)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

beat-Ia^C163/beat-Ia³ is rescued by beat-Ia^UAS.cFa/Scer\GAL4^elav.PLu

(Siebert et al., 2009)

beat-Ia^C163/beat-Ia³ is rescued by beat-Ia^UAS.cFa/Scer\GAL4^Fas2-Mz507

(Siebert et al., 2009)

Not rescued by

beat-Ia^C163/beat-Ia³ is not rescued by beat-Ia^UAS.cFa/Scer\GAL4^Mef2.PR