FB2024_03 , released June 25, 2024
Allele: Dmel\Syx1AL371
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General Information
Symbol
Dmel\Syx1AL371
Species
D. melanogaster
Name
FlyBase ID
FBal0065669
Feature type
allele
Associated gene
Dmel\Syx1A
Associated Insertion(s)
Carried in Construct
Also Known As
syxL371
Key Links
Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Burgess et al., 1997)
Mutagen
P-element activity
(Burgess et al., 1997)
Progenitor genotype
Cytology
Description

Deletion of approximately 1700bp removing 5' untranslated sequences and the first third of the open reading frame. The deletion is flanked by two P{lacZ} elements.

(Burgess et al., 1997)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Nerve evoked excitatory synaptic currents (ESCs) and mESCs have not been detected in mutant embryos (during observations exceeding 15 minutes). Glutamate-evoked currents are much smaller than wild type.

      (Saitoe et al., 2001)

      Viable, adult heterozygous flies containing a homozygous mutant eye (generated by mitotic recombination using the "EGUF/hid method") are recovered. Photoreceptors are absent from these eyes. The electroretinogram shows no light-dependent changes in electrical activity.

      (Stowers and Schwarz, 1999)

      Females with homozygous germline clones fail to produce any oocytes. Syx1AL266/Syx1AL371 embryos derived from females with homozygous Syx1AL266 germline clones arrest very early, usually before germ band extension. Syx1AL266/Syx1AL371 mitotic cycle 14 embryos derived from females with homozygous Syx1AL266 germline clones have large acellular patches. Within these patches the actin cytoskeleton is completely absent and the nuclei are disorganised and begin to fall away from the surface of the embryo.

      (Burgess et al., 1997)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      Syx1AL371 is an enhancer of visible phenotype of Nsf2EQ.UAS, Scer\GAL4bbg-C96

      (Stewart et al., 2001)
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      Syx1AL371 is an enhancer of wing margin phenotype of Nsf2EQ.UAS, Scer\GAL4bbg-C96

      (Stewart et al., 2001)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      Syx1AL371 is rescued by Syx1AUAS.cBa/Scer\GAL4elav.PLu

      (Saitoe et al., 2001)

      Syx1AL371 is rescued by Syx1AUAS.cBa/Scer\GAL4hs.PB

      (Burgess et al., 1997)
      Not rescued by

      Syx1AL371 is not rescued by Scer\GAL4G14/Syx1AUAS.cBa

      (Saitoe et al., 2001)
      Comments

      The oocyte phenotype is rescued by Syx1AScer\UAS.cBa expressed under the control of Scer\GAL4hs.PB.

      (Burgess et al., 1997)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      Df(3R)L371
      (Burgess et al., 1997)
      Syx1AL371
      syx1AL371
      syxL371
      (Stewart, 2002, Saitoe et al., 2001, Stewart et al., 2001, Stowers and Schwarz, 1999, Burgess et al., 1997)
      Name Synonyms
      Secondary FlyBase IDs
        References (6)