FlyBase Allele Report: Dmel\bif[R38]

General Information

Symbol

Dmel\bif^R38

Species

D. melanogaster

Name

FlyBase ID

FBal0064946

Feature type

allele

Associated gene

Dmel\bif

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

Delta2-3 transposase

Nature of the Allele

Allele class

Mutagen

Delta2-3 transposase

(Bahri et al., 1997)

Progenitor genotype

P{wA^R}PhKγ^P842

(Bahri et al., 1997)

Cytology

Description

Internal deletion in bif, removing 2kb of exon 3.

(Bahri et al., 1997)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy

(Ruan et al., 2002)

abnormal neuroanatomy | third instar larval stage

(Kurusu and Zinn, 2008)

Phenotype Manifest In

medial lobe of larval mushroom body | third instar larval stage

(Kurusu and Zinn, 2008)

photoreceptor cell R2 & axon

(Ruan et al., 2002)

photoreceptor cell R3 & axon

(Ruan et al., 2002)

photoreceptor cell R4 & axon

(Ruan et al., 2002)

photoreceptor cell R5 & axon

(Ruan et al., 2002)

rhabdomere

(Zelhof et al., 2001)

Detailed Description

Statement

Reference

Many R2-R5 photoreceptor axons project abnormally through the lamina into the medulla layer in mutant larvae.

(Ruan et al., 2002)

Homozygotes have split and elongated rhabdomeres.

(Zelhof et al., 2001)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

bif^R38/bif[+] is a suppressor of abnormal neuroanatomy phenotype of Scer\GAL4^GMR.PF, msn^EP549

(Ruan et al., 2002)

Other

Statement

Reference

Df(2L)Prl, bif^R38 has visible | recessive phenotype

(Bahri et al., 1997)

Phenotype Manifest In

Suppressed by

Statement

Reference

bif^R38 has rhabdomere phenotype, suppressible by Amph[+]/Amph²⁶

(Zelhof et al., 2001)

Suppressor of

Statement

Reference

bif^R38/bif[+] is a suppressor of photoreceptor cell & axon phenotype of Scer\GAL4^GMR.PF, msn^EP549

(Ruan et al., 2002)

Other

Statement

Reference

Df(2L)Prl, bif^R38 has eye phenotype

(Bahri et al., 1997)

Additional Comments

Genetic Interactions

Statement

Reference

The defects in photoreceptor cell projection patterns seen in larvae overexpressing msn^EP549 under the control of Scer\GAL4^GMR.PF are largely suppressed by one copy of bif^R38.

(Ruan et al., 2002)

The bif^R38/Y phenotype is partially rescued by Amph²⁶/+; fewer rhabdomeres are split and elongated.

(Zelhof et al., 2001)

bif^R38/Y ; Df(2L)Prl/+ flies have rough eyes.

(Bahri et al., 1997)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially rescued by

bif^R38 is partially rescued by bif^UAS.cRa/Scer\GAL4^GMR.PF

(Ruan et al., 2002)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

R38

(Bahri et al., 1997)

bif^R38

(Kurusu and Zinn, 2008)

Name Synonyms

Secondary FlyBase IDs

References (4)

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