FlyBase Allele Report: Dmel\bif[UAS.cRa]

General Information

Symbol

Dmel\bif^UAS.cRa

Species

D. melanogaster

Name

Saccharomyces cerevisiae UAS construct a of Ruan

FlyBase ID

FBal0147267

Feature type

allele

Associated gene

Dmel\bif

Associated Insertion(s)

Carried in Construct

P{UAS-bif.R}

Key Links

Transgenic product class

wild_type

(Ruan et al., 2002)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Ruan et al., 2002)

Mutagen

in vitro construct

(Ruan et al., 2002)

Progenitor genotype

Carried in construct

P{UAS-bif.R}

Cytology

Description

UAS regulatory sequences drive expression of bif.

(Ruan et al., 2002)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

bif

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy, with Scer\GAL4^GMR.PF

(Ruan et al., 2002)

abnormal neuroanatomy, with Scer\GAL4^sev.PM181

(Ruan et al., 2002)

Phenotype Manifest In

lamina plexus, with Scer\GAL4^GMR.PF

(Ruan et al., 2002)

medulla, with Scer\GAL4^GMR.PF

(Ruan et al., 2002)

photoreceptor cell R1 & axon, with Scer\GAL4^GMR.PF

(Ruan et al., 2002)

photoreceptor cell R2 & axon, with Scer\GAL4^GMR.PF

(Ruan et al., 2002)

photoreceptor cell R3 & axon, with Scer\GAL4^GMR.PF

(Ruan et al., 2002)

photoreceptor cell R4 & axon, with Scer\GAL4^GMR.PF

(Ruan et al., 2002)

photoreceptor cell R5 & axon, with Scer\GAL4^GMR.PF

(Ruan et al., 2002)

photoreceptor cell R6 & axon, with Scer\GAL4^GMR.PF

(Ruan et al., 2002)

photoreceptor cell R7 & axon, with Scer\GAL4^sev.PM181

(Ruan et al., 2002)

photoreceptor neuron, with Scer\GAL4^GMR.PF

(Ruan et al., 2002)

Detailed Description

Statement

Reference

Animals carrying one copy of bif^Scer\UAS.cRa expressed under the control of Scer\GAL4^GMR.PF show a mild defect in the R1-R6 termination layer. The lamina plexus is often split due to uneven termination of R1-R6 growth cones, while the R7 and R8 termination field in the medulla is largely normal. When two copies of bif^Scer\UAS.cRa are present, the phenotype is more severe; the number of prematurely terminated R cell axons increases dramatically and the R7 and R8 terminal field is severely disrupted. In addition, the organisation of photoreceptor cell clusters in the eye disc is severely disrupted, with many photoreceptor cell bodies migrating abnormally towards the most posterior end and accumulating at the entry point of the optic stalk. A small number of R7 axons terminate within the lamina soon after exiting the optic stalk in animals expressing bif^Scer\UAS.cRa under the control of Scer\GAL4^sev.PM181.

(Ruan et al., 2002)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhanced by

Statement

Reference

Scer\GAL4^GMR.PF, bif^UAS.cRa has abnormal neuroanatomy phenotype, non-enhanceable by msn¹⁰²

(Ruan et al., 2002)

NOT suppressed by

Statement

Reference

Scer\GAL4^GMR.PF, bif^UAS.cRa has abnormal neuroanatomy phenotype, non-suppressible by msn¹⁰²

(Ruan et al., 2002)

Phenotype Manifest In

NOT Enhanced by

Statement

Reference

Scer\GAL4^GMR.PF, bif^UAS.cRa has photoreceptor cell R1 & axon phenotype, non-enhanceable by msn¹⁰²

(Ruan et al., 2002)

Scer\GAL4^GMR.PF, bif^UAS.cRa has photoreceptor cell R2 & axon phenotype, non-enhanceable by msn¹⁰²

(Ruan et al., 2002)

Scer\GAL4^GMR.PF, bif^UAS.cRa has photoreceptor cell R3 & axon phenotype, non-enhanceable by msn¹⁰²

(Ruan et al., 2002)

Scer\GAL4^GMR.PF, bif^UAS.cRa has photoreceptor cell R4 & axon phenotype, non-enhanceable by msn¹⁰²

(Ruan et al., 2002)

Scer\GAL4^GMR.PF, bif^UAS.cRa has photoreceptor cell R5 & axon phenotype, non-enhanceable by msn¹⁰²

(Ruan et al., 2002)

Scer\GAL4^GMR.PF, bif^UAS.cRa has photoreceptor cell R6 & axon phenotype, non-enhanceable by msn¹⁰²

(Ruan et al., 2002)

NOT suppressed by

Statement

Reference

Scer\GAL4^GMR.PF, bif^UAS.cRa has photoreceptor cell R1 & axon phenotype, non-suppressible by msn¹⁰²

(Ruan et al., 2002)

Scer\GAL4^GMR.PF, bif^UAS.cRa has photoreceptor cell R2 & axon phenotype, non-suppressible by msn¹⁰²

(Ruan et al., 2002)

Scer\GAL4^GMR.PF, bif^UAS.cRa has photoreceptor cell R3 & axon phenotype, non-suppressible by msn¹⁰²

(Ruan et al., 2002)

Scer\GAL4^GMR.PF, bif^UAS.cRa has photoreceptor cell R4 & axon phenotype, non-suppressible by msn¹⁰²

(Ruan et al., 2002)

Scer\GAL4^GMR.PF, bif^UAS.cRa has photoreceptor cell R5 & axon phenotype, non-suppressible by msn¹⁰²

(Ruan et al., 2002)

Scer\GAL4^GMR.PF, bif^UAS.cRa has photoreceptor cell R6 & axon phenotype, non-suppressible by msn¹⁰²

(Ruan et al., 2002)

Additional Comments

Genetic Interactions

Statement

Reference

The photoreceptor projection phenotype caused by expression of bif^Scer\UAS.cRa under the control of Scer\GAL4^GMR.PF is not modified by msn¹⁰².

(Ruan et al., 2002)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially rescues

bif^UAS.cRa/Scer\GAL4^GMR.PF partially rescues bif^R38

(Ruan et al., 2002)

Comments

Expression of bif^Scer\UAS.cRa under the control of Scer\GAL4^GMR.PF largely rescues the R1-R6 targeting defects seen in bif^R38/Y larvae.

(Ruan et al., 2002)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

bif^Scer\UAS.cRa

bif^UAS.cRa

Name Synonyms

Saccharomyces cerevisiae UAS construct a of Ruan

(Ruan et al., 2002)

Secondary FlyBase IDs

References (1)

Report Sections

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